|
| 2,2'-Dithiosalicylic acid Basic information |
Product Name: | 2,2'-Dithiosalicylic acid | Synonyms: | 2,2'-Dithiodibenzoic acid >=95.0% (NT);2,2’-dithiobis(benzoicacid);2,2’-dithiobis-benzoicaci;Thimerosal Related Compound A;2,2'-DITHIOSALICYLIC ACID, TECH., 85%;2-Hydroxybenzenecarbothioic acid;2-Carboxyphenyl disulfide, Bis(2-carboxyphenyl) disulfide, Dithiosalicylic acid;2,2'-DITHIOBENZOCI ACID | CAS: | 119-80-2 | MF: | C14H10O4S2 | MW: | 306.36 | EINECS: | 204-352-8 | Product Categories: | pharmacetical;Organic acids;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Halogenated Heterocycles ,Pyrimidines;119-80-2 | Mol File: | 119-80-2.mol | ![2,2'-Dithiosalicylic acid Structure](CAS/GIF/119-80-2.gif) |
| 2,2'-Dithiosalicylic acid Chemical Properties |
Melting point | 287-290 °C(lit.) | Boiling point | 416.97°C (rough estimate) | density | 1.4555 (rough estimate) | vapor pressure | 0Pa at 25℃ | refractive index | 1.4950 (estimate) | storage temp. | Refrigerator | solubility | DMSO (Slightly), Methanol (Slightly) | form | Powder | pka | 3.02±0.36(Predicted) | color | Brown | Water Solubility | insoluble | BRN | 2221810 | InChIKey | LBEMXJWGHIEXRA-UHFFFAOYSA-N | LogP | 1.61 at 25℃ and pH6.2-6.48 | CAS DataBase Reference | 119-80-2(CAS DataBase Reference) | EPA Substance Registry System | Benzoic acid, 2,2'-dithiobis- (119-80-2) |
Hazard Codes | Xi | Risk Statements | 36/37/38 | Safety Statements | 26-36-24/25 | WGK Germany | 3 | RTECS | DG9660000 | Hazard Note | Harmful/irritant | TSCA | Yes | HS Code | 29309070 | Toxicity | LD50 ipr-mus: 367 mg/kg ARZNAD 21,284,71 |
| 2,2'-Dithiosalicylic acid Usage And Synthesis |
Chemical Properties | brown powder | Uses | 2,2'-Dithiosalicylic acid is an organosulfur compound produced from dibenzothiophene metabolites that is in turn biodegraded into transient metabolites such as benzoic acid.It is used in the preparation of a new class of anti-HIV-1 agents. | Uses | 2,2′-Dithiodibenzoic acid may be used for the preparation of novel anionic heptadecanuclear silver(I) cluster, by the reaction with equivalent molar silver oxide under ultrasonic conditions at 50°C. It may be used for the preparation of polyamides containing a disulfide bond in their main chain. | General Description | 2,2′-Dithiodibenzoic acid is an sulfhydryl modifying reagent. 2,2′-Dithiodibenzoic acid on cocrystallization with imidazole or 4-methylimidazole affords bis(imidazolium) 2,2′-dithiodibenzoate and 4-methylimidazolium 2-[(2-carboxyphenyl)disulfanyl]benzoate organic salt, respectively. It also cocrystallizes with isonicotinohydrazide from methanol solution to afford the 1:2 cocrystal, 2,2′-dithiodibenzoic acid-isonicotinohydrazide. | Safety Profile | Poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofSOx. | Synthesis | A preparation method of 2,2'-dithiosalicylic acid is as follows: using anthranilic acid as raw material and performing a diazotization reaction with sodium nitrite and hydrochloric acid at 0 to 10°C to obtain a diazo liquid. The liquid reacts with liquid sulfur dioxide for 0.5 to 3 hours in the presence of a catalyst and a cocatalyst at -20~~-10°C and then is kept at 80~100°C for 0.5~2 hours, cooled, and filtered to obtain 2,2'-Dithiosalicylic acid.
|
| 2,2'-Dithiosalicylic acid Preparation Products And Raw materials |
|