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Shanghai T&W Pharmaceutical Co., Ltd.
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Product Name:2-bromo-6beta,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate)
CAS:57781-14-3
Purity:98% Package:50kg;25kg;10kg;5kg;500g;500mg;
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| | 2-bromo-6beta,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate) Basic information |
| Product Name: | 2-bromo-6beta,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate) | | Synonyms: | Haloart;halopredone acetate;2-bromo-6beta,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate);Pregna-1,4-diene-3,20-dione, 17,21-bis(acetyloxy)-2-bromo-6,9-difluoro-11-hydroxy-, (6β,11β)-;THS 201;Topicon;17,21-Bis(acetyloxy)-2-bromo-6β,9-difluoro-11β-hydroxypregna-1,4-diene-3,20-dione;17α,21-Bis(acetyloxy)-2-bromo-6β,9-difluoro-11β-hydroxypregna-1,4-diene-3,20-dione | | CAS: | 57781-14-3 | | MF: | C25H29BrF2O7 | | MW: | 559.39 | | EINECS: | 260-951-4 | | Product Categories: | | | Mol File: | 57781-14-3.mol |  |
| | 2-bromo-6beta,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate) Chemical Properties |
| Melting point | 290-292° (dec) | | alpha | D24 -36° (c = 1 in chloroform) | | density | 1.3611 (rough estimate) | | refractive index | 1.3760 (estimate) |
| | 2-bromo-6beta,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate) Usage And Synthesis |
| Originator | Topicon,Pierrel,Italy,1983 | | Uses | Anti-inflammatory (topical). | | Definition | ChEBI: Halopredone acetate is an organic molecular entity. | | Manufacturing Process | 100 ml of a 70% hydrofluoric acid aqueous solution were cooled to -10°C in a
polyethylene flask equipped with electromagnetic stirrer. 10 g of 2-bromo-6β-
fluoro-17α,21-dihydroxy-9β, 11β-oxido-pregna-1,4-diene-3,20-dione-17,21-
diacetate were added under stirring during 15 minutes. After 0.5 hour the
reaction mixture was precipitated in water and ammonia. The solid was
collected by filtration, washed with water and dried to a constant weight,
giving about 9.5 g of 2-bromo-6β,9α-difluoro-11β,17α,21 -trihydroxypregna-
1,4-diene-3,20-dione-17,21-diacetate. | | Therapeutic Function | Topical antiinflammatory |
| | 2-bromo-6beta,9-difluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 17,21-di(acetate) Preparation Products And Raw materials |
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