雌莫司汀磷酸钠
| 中文名称 | 雌莫司汀磷酸钠 |
|---|---|
| 中文同义词 | 雌莫司汀磷酸钠;雌莫司丁磷酸钠;雌莫司汀磷酸钠, 抗微管蛋白化疗试剂;(8R,9S,13S,14S,17S)-3-((双(2-氯乙基)氨基甲酰基)氧基)-13-甲基-7,8,9,11,12,13,14,15,16,17-十氢-6H-环戊二烯[A]菲-17-基磷酸二钠 |
| 英文名称 | Estramustine sodium phosphate |
| 英文同义词 | ESTRAMUSTINE PHOSPHATE SODIUM;-(dihydrogenphosphate),disodiumsalt;iumphosphate;Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt;Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt;Estracyt;Estramustine phosphate disodium salt;NSC 89199 |
| CAS号 | 52205-73-9 |
| 分子式 | C23H33Cl2NNaO6P |
| 分子量 | 544.38 |
| EINECS号 | 257-735-7 |
| 相关类别 | 医药原料药;医药、农药及染料中间体;化学试剂;Active Pharmaceutical Ingredients;Intermediates;Other APIs |
| Mol文件 | 52205-73-9.mol |
| 结构式 |  |
雌莫司汀磷酸钠 性质
| 储存条件 | Inert atmosphere,2-8°C |
|---|---|
| 溶解度 | H2O中可溶50mg/mL |
| 形态 | 结晶固体 |
| 颜色 | 白色至米白色 |
| 稳定性 | 吸湿性，溶液不稳定 |
| CAS 数据库 | 52205-73-9(CAS DataBase Reference) |
Estramustine phosphate sodium (1 µg/mL) treatment suppressed PC3 cell growth.
Estramustine phosphate sodium (2 µg/mL) treatment significantly elevates phosphatidylserine eversion amount on PC3 cells. Estramustine phosphate sodium induces PC3 cell apoptosis.
Estramustine phosphate sodium (2 µg/mL) treatment decreases MiR-31 level. Estramustine phosphate odium induces s prostate cancer cell line PC3 apoptosis through reducing miR-31.
Estramustine phosphate sodium, a unique antitumour agent, is selectively taken up by prostate cells and exerts antineoplastic effects by interfering with microtubule of dynamics and by reducing plasma levels of testosterone.
Estrone and estradiol, products of the metabolism of Estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels similar to those achieved after surgical castration.
Estramustine phosphate sodium (4-12 mg/kg; intraperitoneal injection; daily; for 2 weeks) inhibits PAC120 tumor growth 53% by day 35.
| Animal Model: | Swiss nu/nu (nude) male mice (5-week-old) bearing PAC120 tumors |
| Dosage: | 4 mg/kg, 12 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 2 weeks |
| Result: | Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-13627 | Estramustine phosphate sodium | 5 mg | 290元 | |
| 2024/11/08 | HY-13627 | 雌莫司汀磷酸钠 Estramustine phosphate sodium | 52205-73-9 | 10mM * 1mLin Water | 360元 |