- Fmoc-AEEA-OH
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- $0.00 / 1kg
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2024-11-22
- CAS:166108-71-0
- Min. Order: 0.10000000149011612kg
- Purity: 98%;99%
- Supply Ability: 1T+
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| | Fmoc-8-amino-3,6-dioxaoctanoic acid Basic information |
| Product Name: | Fmoc-8-amino-3,6-dioxaoctanoic acid | | Synonyms: | Fmoc-8-amino-3,6-dioxaoctanoic acid,
Fmoc-AEEA;Fmoc-PEG2-acetic acid;{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid≥ 99% (HPLC);Fmoc-NH-(PEG)-COOH (9 atoms) Novabiochem;1-(9H-Fluoren-9-yl)-3-oxo-2,7,1-trioxa-4-azadodecan-12-oic acid;8-(FMOC-AMINO)-3,6-DIOXA-OCTANOIC ACID;8-FLUORENYLMETHOXYCARBONYLAMINO-3,6-DIOXAOCTANOIC ACID;8-(9-FLUORENYLMETHOXYCARBONYL-AMINO)-3,6-DIOXA-OCTANOIC ACID | | CAS: | 166108-71-0 | | MF: | C21H23NO6 | | MW: | 385.41 | | EINECS: | 200-111-8 | | Product Categories: | peg;166108-71-0;ADC Linker | | Mol File: | 166108-71-0.mol |  |
| | Fmoc-8-amino-3,6-dioxaoctanoic acid Chemical Properties |
| Melting point | 90-92℃ | | Boiling point | 631.4±45.0 °C(Predicted) | | density | 1.265±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,2-8°C | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | | pka | 3.40±0.10(Predicted) | | form | Crystalline Powder | | color | White | | InChI | InChI=1S/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24) | | InChIKey | XQPYRJIMPDBGRW-UHFFFAOYSA-N | | SMILES | C(O)(=O)COCCOCCNC(=O)OCC1C2=C(C=CC=C2)C2=C1C=CC=C2 | | CAS DataBase Reference | 166108-71-0(CAS DataBase Reference) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 29189900 |
| | Fmoc-8-amino-3,6-dioxaoctanoic acid Usage And Synthesis |
| Description | Fmoc-NH-PEG2-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Chemical Properties | White solid | | Uses | 8-(Fmoc-amino)-3,6-dioxaoctanoic Acid is a hydrophilic, heterobifunctional spacer. | | Uses | Hydrophillic spacer group. | | Application | Fmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable ADC linker for the synthesis of antibody-drug couplings (ADCs). It is also a PEG linker for the synthesis of PROTAC. It is widely used in drug delivery systems as it is mainly used to enhance the solubility or targeting of drugs and improve their bioavailability. |
| | Fmoc-8-amino-3,6-dioxaoctanoic acid Preparation Products And Raw materials |
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