2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide

2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Suppliers list

Company Name:	career henan chemical co
Tel:	+86-0371-86658258 +8613203830695
Email:	factory@coreychem.com
Products Intro:	Product Name:Benzeneacetamide, α-phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]- CAS:313254-51-2 Purity:98%; 99% Package:1KG;0.01USD

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354 +1-00000000000
Email:	marketing@targetmol.com
Products Intro:	Product Name:ICA-121431 CAS:313254-51-2 Purity:98% Package:5mg;64USD\|10mg;90USD\|25mg;158USD Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	InvivoChem
Tel:	+1-708-310-1919 +1-13798911105
Email:	sales@invivochem.cn
Products Intro:	Product Name:ICA-121431 CAS:313254-51-2 Purity:98% Package:5mg Remarks:V2997

Company Name:	TargetMol Chemicals Inc.
Tel:
Email:	support@targetmol.com
Products Intro:	Product Name:ICA-121431；2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl CAS:313254-51-2 Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel:	13417589054
Email:	trendseenbio@gmail.com
Products Intro:	Product Name:ICA-121431 CAS:313254-51-2 Purity:99% Package:1kg；25kg

2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide manufacturers

Benzeneacetamide, α-?phenyl-?N-?[4-?[(2-?thiazolylamino)?sulfonyl]?phenyl]?-
$0.01 / 1KG
2020-01-10
CAS:313254-51-2
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g;1kg； 25kg

2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Basic information

Product Name:	2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide
Synonyms:	ICA-121431;2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide;α-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-benzeneacetamide;alpha-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]benzeneacetamide;2,2-DIPHENYL-N-(4-(N-THIAZOL-2-YLSULFAMOYL)PHENYL) ACETAMIDE;ICA-121431;ICA 121431;ICA121431;Benzeneacetamide, α-phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-;2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl
CAS:	313254-51-2
MF:	C23H19N3O3S2
MW:	449.55
EINECS:	809-095-0
Product Categories:
Mol File:	313254-51-2.mol

2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Chemical Properties

density	1.409±0.06 g/cm3(Predicted)
storage temp.	room temp
solubility	DMSO: soluble20mg/mL, clear
pka	7.03±0.10(Predicted)
form	powder
color	white to beige
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey	URSQNPPONHUJDL-UHFFFAOYSA-N

Safety Information

MSDS Information

2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Usage And Synthesis

Description	ICA 121431 is a voltage-gated sodium channel (Na_v) blocker that selectively blocks Na_v1.1 and Na_v1.3 over Na_v1.4, and Na_v1.5-1.8 channels (IC₅₀s = <20, 19, 240, and >10,000 nM, respectively). It induces a concentration-dependent hyperpolarizing shift in voltage dependence of inactivation of Na_v1.3 channels at a concentration 1 μM but has no effect on resting channels. Substitution of the Na_v1.3 domain IV voltage-sensor domain (VSD4) with the Na_v1.5 VSD4 reduces ICA 121431 potency by approximately 500-fold.
Uses	ICA 121431 is a voltage-gated sodium (Nav) channel inhibitor.
storage	+4°C
References	McCormack et al. (2013), Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels; Proc. Natl. Acad. Sci. USA 110 E2724 Ostenn et al. (2017), Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes; Proc. Natl. Acad. Sci. USA 114 6836

2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Preparation Products And Raw materials

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