ANTI-ALPHA-ACTININ 抗体
| 中文名称 | ANTI-ALPHA-ACTININ 抗体 |
|---|---|
| 中文同义词 | |
| 英文名称 | ANTI-ALPHA-ACTININ Antibody |
| 英文同义词 | MS X ANTI-ACTIN;MONOCLONAL ANTI-ACTIN, ALPHA-SMOOTH MUSCLE;ANTI-ACTIN (SMOOTH MUSCLE);ANTI-ACTIN, SMOOTH MUSCLE (AB-2);ANTI-ACTIN, ALPHA-, HUMAN, SMOOTH MUSCLE;ANTI-ACTIN-ALPHA (SMOOTH MUSCLE, HUMAN);ANTI-ACTININ, ALPHA;ALPHA-ACTININ (AB-1) MONOCLONAL ANTIBODY |
| CAS号 | |
| 分子式 | |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | Antibodies to Actin-associated Proteins/MyosinCardiac Stem Cell Biology;A1-ALCell Biology;Alphabetical Index;Antibodies;Antibodies to Cytoskeleton;Cardiac Stem Cell Tracking;Cardiogenesis Markers;BCardiac Stem Cell Biology;Antibodies to Actin-associated Proteins/MyosinAntibodies;Clone Index |
| Mol文件 | Mol File |
| 结构式 |
ANTI-ALPHA-ACTININ 抗体 性质
| 储存条件 | −20°C |
|---|
小鼠单克隆抗体 to alpha Actinin
Mouse
Mouse
与反应: Mouse, Rat, Human, African green monkey
Recombinant fragment corresponding to Human alpha Actinin/ACTN1 aa 650-893. Protein produced in E.coli. Database link: NP_001093
Western blot - Anti-alpha Actinin/ACTN1 antibody(ab90421)
All lanes : Anti-alpha Actinin/ACTN1 antibody [OTI7A4] (ab90421) at 1/200 dilution
Lane 1 : HepG2 (Human liver hepatocellular carcinoma cell line) extracts
Lane 2 : HeLa (Human epithelial cell line from cervix adenocarcinoma) extracts
Lane 3 : SVT2 (Mouse cell line) extracts
Lane 4 : A549 (Human lung carcinoma cell line) extracts
Lane 5 : COS-7 (African green monkey kidney fibroblast-like cell line) extracts
Lane 6 : Jurkat (Human T cell leukemia cell line from peripheral blood) extracts
Lane 7 : PC-12 (Rat adrenal gland pheochromocytoma cell line) extracts
Lane 8 : MCF7 (Human breast adenocarcinoma cell line) extracts
Lysates/proteins at 10 µg per lane.
Predicted band size: 103 kDa
辅肌动蛋白有辅肌动蛋白-1、2、3和4四种类型,呈细胞或组织特异性分布.这四种蛋白的共同结构特征是在细胞内均为反向平行的二聚体,并具有N末端肌动蛋白结合结构域(ABD)、血影蛋白样中央重复结构域和C末端"EF手"结构域。
作为细胞骨架中一种重要的肌动蛋白交联蛋白,辅肌动蛋白通过与其相关蛋白包括整合素(integrins)、钙粘素(cadherin)以及细胞信号传导通路中的信号分子等,例如斑联蛋白（zyxin）的协同作用,在稳定细胞粘附、调节细胞形状及细胞运动中发挥着重要作用。因此,肿瘤的发生、发展和恶化与辅肌动蛋白的结构、功能密切相关。
ANTI-ALPHA-ACTININ用于2型糖尿病患者尿液α-actinin-4含量与糖尿病痛病相关性探讨研究。
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英文
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