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BMS-265246

BMS-265246 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:BMS-265246
CAS:582315-72-8
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
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Products Intro: Product Name:BMS-265246
CAS:582315-72-8
Purity:0.99 Package:5KG;1KG
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:BMS-265246;BMS265246;BMS 265246
CAS:582315-72-8
Purity:99.55% Package:1 mg;1 mL * 10mM (in DMSO);10 mg;100 mg;2 mg;25 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Dideu Industries Group Limited
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Products Intro: Product Name:BMS-265246
CAS:582315-72-8
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:BMS-265246 BMS265246
CAS:582315-72-8
Purity:99% Package:5KG;1KG
BMS-265246 Basic information
Product Name:BMS-265246
Synonyms:BMS-265246;BMS-265246, >=98%;(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone;(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone BMS265246;BMS265246; BMS 265246;CS-984;Methanone, (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-;BMS-265246 USP/EP/BP
CAS:582315-72-8
MF:C18H17F2N3O2
MW:345.34
EINECS:
Product Categories:Inhibitors
Mol File:582315-72-8.mol
BMS-265246 Structure
BMS-265246 Chemical Properties
Boiling point 552.9±50.0 °C(Predicted)
density 1.304±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥17.25 mg/mL in DMSO
form solid
pka8.50±0.40(Predicted)
color White to pink
Safety Information
MSDS Information
BMS-265246 Usage And Synthesis
UsesBMS-265246 is a potent and selective pyra-zolopyridine based inhibitor of cdk2/cyclinE, cdk1/cyclinB and cdk4/ cyclinD.
Biological Activitybms265246 is a potent and selective inhibitor for cdk1 and cdk2 (ic50= 6 nm and 9 nm)cyclin-dependent kinases (cdk) are a group of serine/threonine kinases. they are activated by coupling to cyclin and participate in the regulation of cell cycle.bms265246 inhibited the cdk4/cycd activity and prevented a2780 cytox (ic50 = 0.23 μm and 0.76 μm) [1]. in hct-116 cells, bms-265246 blocked the cell proliferation (ec50= 0.293 μm—0.492 μm). following the treatment of bms-265246, low dna intensity, large round nuclei and 4n dna content were observed in the dominant cell population –g2 arrested cells. [2]
storageStore at -20°C
references1. misra rn, xiao hy, rawlins db et al. 1h-pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-difluorophenacyl analogues. bioorgmed chem lett. 2003 jul 21;13(14):2405-8.2. sutherland jj, low j, blosser w et al. a robust high-content imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators. mol cancer ther. 2011 feb;10(2):242-54.
BMS-265246 Preparation Products And Raw materials
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