APTSTAT3-9R
| 中文名称 | APTSTAT3-9R |
|---|---|
| 中文同义词 | 结合肽APTSTAT3-9R |
| 英文名称 | APTSTAT3-9R |
| 英文同义词 | APTSTAT3-9R |
| CAS号 | |
| 分子式 | C223H330N80O51 |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | Mol File |
| 结构式 |
APTSTAT3-9R 性质
| 形态 | 固体 |
|---|---|
| 颜色 | 白色至米白色 |
|
STAT3
|
APTSTAT3-9R (7.5, 15, and 30 μmol/L; 6 hours) significantly reduces STAT3–DNA-binding activity in a dose-dependent manner in human lung carcinoma cells (A549).
APTSTAT3-9R (30 μM; for 2 weeks) suppresses cell viability and proliferation of cancer cells and significantly suppresses colony formation. APTSTAT3-9R has IC50s of 10 to 20 μM in A549, B16F1 and HepG2 cells.
APTSTAT3-9R (7.5, 15, and 30 μmol/L; 6 hours) effectively inhibits phosphorylation of STAT3 but does not affect the level of AKT phosphorylation, indicating specificity of the aptide.
APTSTAT3-9R (8 mg/kg in 50 μL; intratumorally injected every other day for a total of four injections) suppresses tumor growth in 6-week-old female BALB/c nude mice with A549 cells.