| Company Name: |
Shanghai YuZn Pharm. Technology Co.,Ltd. Gold
|
| Tel: |
15921286451; 15921286451 |
| Email: |
2010681527@qq.com |
| Products Intro: |
Product Name:Brivaracetam Impurity 2
CAS:1928755-17-2
Purity:97% HPLC Package:100mg;250mg; 500mg;1g
|
|
| | tert-butyl (R)-3-(hydroxymethyl)hexanoate Basic information |
| Product Name: | tert-butyl (R)-3-(hydroxymethyl)hexanoate | | Synonyms: | Brivaracetam Impurity 6;(R)-tert-Butyl 3-(hydroxymethyl)hexanoate;Hexanoic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R)-;(R)-tert-Butyl 3-(hydroxymethyl)hexanoate (Brivaracetam Impurity);Buvacitan impurity 2 | | CAS: | 1928755-17-2 | | MF: | C11H22O3 | | MW: | 202.29 | | EINECS: | | | Product Categories: | | | Mol File: | 1928755-17-2.mol |  |
| | tert-butyl (R)-3-(hydroxymethyl)hexanoate Chemical Properties |
| Boiling point | 278.5±23.0 °C(Predicted) | | density | 0.956±0.06 g/cm3(Predicted) | | pka | 14.78±0.10(Predicted) |
| | tert-butyl (R)-3-(hydroxymethyl)hexanoate Usage And Synthesis |
| Uses | Tert-butyl (R)-3-(hydroxymethyl)hexanoate is employed in the biocatalytic route to the novel antiepileptic drug brivaracetam. | | Synthesis | Sodium borohydride was slowly added to pre-cooled tetrahydrofuran at -5-0°C and stirred for 5 min. BF3-etherate (25.6 g) was slowly added to the reaction mixture at -5-0°C and stirred for 15 min at the same temperature. (R)-2-(2-(tert-butoxy)-2-oxoethyl)pentanoic acid (23 g) was added to the reaction mixture and stirred for 3 h. The reaction mixture was slowly quenched with water and raised the temperature of the reaction mixture to 25-30°C. Separated both the aqueous and organic layers and the aqueous layer was extracted with ethyl acetate. Combined the organic layers and washed with aqueous sodium chloride solution. Distilled off solvent completely from the organic layer to get tert-butyl (R)-3-(hydroxymethyl)hexanoate.Yield: 16.2 g.
 |
| | tert-butyl (R)-3-(hydroxymethyl)hexanoate Preparation Products And Raw materials |
|