|
|
| | 2-Benzofurancarboxylic acid ethyl ester Basic information |
| Product Name: | 2-Benzofurancarboxylic acid ethyl ester | | Synonyms: | BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER;BENZOFURAN-2-CARBOXLIC ACID ETHYL ESTER;Ethyl benzo[b]furan-2-carboxylate 97%;RARECHEM AL BI 0556;2-BENZOFURANCARBOXYLIC ACID, ETHYL ESTER;ethyl benzofuran-2-carboxylate;Ethyl 2-benzofurancarboxylate;2-(Ethoxycarbonyl)benzo[b]furan, Ethyl 1-benzofuran-2-carboxylate | | CAS: | 3199-61-9 | | MF: | C11H10O3 | | MW: | 190.2 | | EINECS: | | | Product Categories: | Miscellaneous | | Mol File: | 3199-61-9.mol |  |
| | 2-Benzofurancarboxylic acid ethyl ester Chemical Properties |
| Melting point | 166-170℃ | | Boiling point | 105°/0.1mm | | density | 1.1656 | | refractive index | 1.5640 (estimate) | | Fp | >110℃ | | storage temp. | 2-8°C | | CAS DataBase Reference | 3199-61-9(CAS DataBase Reference) |
| Hazard Codes | T | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2932190090 |
| | 2-Benzofurancarboxylic acid ethyl ester Usage And Synthesis |
| Uses | Ethyl Coumarilate has been used as a reactant for the preparation of benzofuropyridines that have a high affinity for the α2-adrenoceptor. | | Preparation | Synthesis of ethyl benzofuran-2-carboxylate: Salicylaldehyde (20.0 mL, 0.164 mol) and diethyl bromomalonate (40.0 mL, 0.168 mol) in ethyl methyl ketone (40.0 mL, 0.555 mol) was treated with anhydrous potassium carbonate (20.0 g,0.869 mol). The reaction mixture was refluxed for 18 h on steam bath. Ethyl methyl ketone was distilled off under reduced pressure and the residue formed was dissolved in 400 mL of water and cooled in an ice-bath. It was acidified with dil H2SO4. The product formed was extracted with 25 mL portion of solvent ether twice and the extract was washed with sodium bicarbonate solution. It was dried over calcium chloride. Solvent was removed and the residue ethyl benzofuran-2-carboxylate was dried. | | Synthesis Reference(s) | Tetrahedron Letters, 27, p. 6315, 1986 DOI: 10.1016/S0040-4039(00)87796-5 |
| | 2-Benzofurancarboxylic acid ethyl ester Preparation Products And Raw materials |
|