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| SB408124 Basic information |
Product Name: | SB408124 | Synonyms: | 1-(6,8-difluoro-2-methylquinolin-4-yl)-3-(4-(dimethylamino)phenyl)urea;SB 4081241-(6,8-difluoro-2-methylquinolin-4-yl)-3-(4-(dimethylamino)phenyl)urea;N-(6,8-DIFLUORO-2-METHYL-4-QUINOLINYL)-N'-[4-(DIMETHYLAMINO)PHENYL]UREA;SB 408124;SB-408124, CID4331799;CS-1990;SB 408124; SB408124;Urea, N-(6,8-difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]- | CAS: | 288150-92-5 | MF: | C19H18F2N4O | MW: | 356.37 | EINECS: | 604-604-1 | Product Categories: | Inhibitors;Orexin receptor | Mol File: | 288150-92-5.mol | ![SB408124 Structure](CAS/GIF/288150-92-5.gif) |
| SB408124 Chemical Properties |
Boiling point | 430.3±45.0 °C(Predicted) | density | 1.371 | storage temp. | Sealed in dry,2-8°C | solubility | DMSO: ~24 mg/mL | form | solid | pka | 12.12±0.43(Predicted) | color | olive-green |
Hazard Codes | Xi | Risk Statements | 36/37/38 | Safety Statements | 26-36 | WGK Germany | 3 |
| SB408124 Usage And Synthesis |
Uses | SB 408124 is a novel OX-1 antagonist. | Definition | ChEBI: 1-(6,8-difluoro-2-methyl-4-quinolinyl)-3-[4-(dimethylamino)phenyl]urea is a member of quinolines and an organohalogen compound. | Biological Activity | Selective non-peptide orexin OX 1 receptor antagonist (K b values are 21.7 and 1405 nM for human OX 1 and OX 2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo . | storage | Store at RT | references | [1] langmead cj1, jerman jc, brough sj, scott c, porter ra, herdon hj.characterisation of the binding of [3h]-sb-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. br j pharmacol. 2004 jan;141(2):340-6. [2] woldan-tambor a1, biegańska k, wiktorowska-owczarek a, zawilska jb. activation of orexin/hypocretin type 1 receptors stimulates camp synthesis in primary cultures of rat astrocytes. pharmacol rep. 2011;63(3):717-23. [3] kis gk1, molnár ah, daruka l, gardi j, rákosi k, lászló f, lászló fa, varga c.the osmotically and histamine-induced enhancement of the plasma vasopressin level is diminished by intracerebroventricularly administered orexin in rats. pflugers arch. 2012 apr;463(4):531-6. |
| SB408124 Preparation Products And Raw materials |
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