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| | Penicillin G potassium salt Basic information |
| | Penicillin G potassium salt Chemical Properties |
| Melting point | 214-217 C | | alpha | D22 +285° (c = 0.748 in water) | | refractive index | 294 ° (C=1, H2O) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | H2O: 100 mg/mL | | form | powder | | color | Needles from butanol (aq) | | PH | pH (10g/L, 25℃) : 5.0～7.5 | | Water Solubility | Soluble in water (100 mg/ml), methanol, ethanol (sparingly), and alcohol. Insoluble in chloroform. | | Merck | 14,7094 | | BRN | 3832841 | | Stability: | Hygroscopic | | InChIKey | IYNDLOXRXUOGIU-LQDWTQKMSA-M | | SMILES | N12C([C@@H](NC(=O)CC3=CC=CC=C3)[C@@]1([H])SC(C)(C)[C@@H]2C([O-])=O)=O.[K+] |&1:2,13,19,r| | | EPA Substance Registry System | Penicillin G Potassium (113-98-4) |
| | Penicillin G potassium salt Usage And Synthesis |
| Description | Benzylpenicillin potassiumwas the first crystalline
penicillin produced on an industrial scale
, . It is produced in the pure state by the
addition of phenylacetate to a culture of Penicillium
chrysogenum. The crystalline benzylpenicillin
potassium contains 1598 U/mg. | | Chemical Properties | Penicillin G potassium salt is also known as Potassium benzylpenicillin, it is white crystalline powder, odorless or slightly specific odor, hygroscopic. Soluble in water, physiological saline, glucose solution. The aqueous solution of it is easy to fail when placed at room temperature, and it will fail rapidly in the presence of acid, alkali, oxidant, etc. Penicillin G potassium salt has good antibacterial effect on Streptococcus such as Streptococcus hemolyticus, Streptococcus pneumoniae and Staphylococcus without penicillinase. | | Uses | Penicillin G is a narrow spectrum antibiotic derived from Streptococcus pneumoniae. Penicillin G potassium salt is used as a cell culture additive as an antibiotics. Use to inhibit the synthesis of bacterial cell walls by inhibition of the cell wall peptidoglycan chain cross-lining. It is the drug of choice for groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridians group streptococci, and non-penicillinase producing staphylococcus. The potassium salt has been used to study murosomes of staphylococci and the penicillin-induced lysis of Streptococcus mutans. | | Definition | ChEBI: Penicillin G potassium salt is organic potassium salt of benzylpenicillin. It is an antibiotic substance produced by Penicillium sp. Antibacterial. It contains a benzylpenicillin(1-). | | Preparation | Penicillin G potassium salt is a highly effective and low toxicity antibiotic, which is obtained by salt formation of Chlorpheniramine maleate and maleic acid. | | Brand name | Pentids (Apothecon); Pfizerpen (Pfizer). | | General Description | Penicillin G Potassium is the potassium salt form of penicillin G, a broad-spectrum penicillin antibiotic. Penicillin G potassium binds to penicillin binding proteins (PBP), the enzymes that catalyze the synthesis of peptidoglycan, which is a critical component of the bacterial cell wall. This leads to the interruption of cell wall synthesis, consequently leading to bacterial cell growth inhibition and cell lysis. | | Biochem/physiol Actions | Mode of Action: Penicillin G acts by inhibiting cell wall synthesis through binding to penicillin binding proteins (PBPs), inhibiting peptidoglycan chain cross-linking.
Antimicrobial spectrum: This product is active against gram-positive and gram-negative bacteria. | | Safety Profile | Poison by intracerebral andintravenous routes. Moderately toxic by intraperitonealroute. Mutation data reported. See other penicillin entries.When heated to decomposition it emits toxic fumes ofNOx and SOx. |
| | Penicillin G potassium salt Preparation Products And Raw materials |
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