他非诺喹
| 中文名称 | 他非诺喹 |
|---|---|
| 中文同义词 | 他非诺喹丁二酸盐;他非诺喹;N4-(2,6-二甲氧基-4-甲基-5-(3-(三氟甲基)苯氧基)喹啉-8-基)戊烷-1,4-二胺;化合物 T13083 |
| 英文名称 | Tafenoquine |
| 英文同义词 | Tafenoquine;4-[5-[3-(Trifluoromethyl)phenoxy]-2,6-dimethoxy-4-methyl-8-quinolinylamino]-1-pentanamine;8-[(4-Amino-1-methylbutyl)amino]-2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinoline;N4-(2,6-diMethoxy-4-Methyl-5-(3-(trifluoroMethyl)phenoxy)quinolin-8-yl)pentane-1,4-diaMine;N4-{2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl}-1,4-pentanediamine;WR 238605; WR238605; WR-238605; SB-252263; SB 252263; SB252263;WR-238605, WR 238605, WR238605, SB-252263-AAB; SB252263-AAB; SB 252263-AAB; TAFENOQUINE; KRINTAFE;Krintafe |
| CAS号 | 106635-80-7 |
| 分子式 | C24H28F3N3O3 |
| 分子量 | 463.49 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 106635-80-7.mol |
| 结构式 |  |
他非诺喹 性质
| 熔点 | 60 - 63°C |
|---|---|
| 沸点 | 565.6±50.0 °C(Predicted) |
| 密度 | 1.237±0.06 g/cm3(Predicted) |
| 储存条件 | 4°C |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 酸度系数(pKa) | 10.36±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 深橙色至极深橙色 |
Tafenoquine (WR 238605) 是一种 8-氨基喹啉。Tafenoquine 作为抗疟疾预防剂。
Anti-malarial
Tafenoquine exhibits no anti-malarial activity in CYP 2D knock-out mice when dosed at their ED 100 values (3 mg/kg) established in WT mice. Tafenoquine anti-malarial activity is partially restored in humanized/CYP 2D6 knock-in mice when tested at two times its ED 100 (6 mg/kg).