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Tafenoquine

Tafenoquine Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Tafenoquine;WR 238605
CAS:106635-80-7
Purity:98.00% Package:100 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:Tafenoquine
CAS:106635-80-7
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: Finetech Industry Limited
Tel: +86-27-87465837 +8618971612321
Email: info@finetechnology-ind.com
Products Intro: Product Name:Tafenoquine
CAS:106635-80-7
Purity:98% Package:1g,10g,25g,100g,500g,1kg
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:Tafenoquine
CAS:106635-80-7
Purity:98% Package:5mg Remarks:V3882
Company Name: TargetMol Chemicals Inc.
Tel:
Email: support@targetmol.com
Products Intro: Product Name:Tafenoquine
CAS:106635-80-7
Package:5mg;193USD|10mg;296USD|25mg;525USD

Tafenoquine manufacturers

  • Tafenoquine
  • Tafenoquine pictures
  • $193.00 / 5mg
  • 2024-10-28
  • CAS:106635-80-7
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  • Supply Ability: 10g

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Tafenoquine Basic information
Product Name:Tafenoquine
Synonyms:Tafenoquine;4-[5-[3-(Trifluoromethyl)phenoxy]-2,6-dimethoxy-4-methyl-8-quinolinylamino]-1-pentanamine;8-[(4-Amino-1-methylbutyl)amino]-2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinoline;N4-(2,6-diMethoxy-4-Methyl-5-(3-(trifluoroMethyl)phenoxy)quinolin-8-yl)pentane-1,4-diaMine;N4-{2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl}-1,4-pentanediamine;WR 238605; WR238605; WR-238605; SB-252263; SB 252263; SB252263;WR-238605, WR 238605, WR238605, SB-252263-AAB; SB252263-AAB; SB 252263-AAB; TAFENOQUINE; KRINTAFE;Krintafe
CAS:106635-80-7
MF:C24H28F3N3O3
MW:463.49
EINECS:
Product Categories:
Mol File:106635-80-7.mol
Tafenoquine Structure
Tafenoquine Chemical Properties
Melting point 60 - 63°C
Boiling point 565.6±50.0 °C(Predicted)
density 1.237±0.06 g/cm3(Predicted)
storage temp. 4°C
solubility DMSO (Slightly), Methanol (Slightly)
pka10.36±0.10(Predicted)
form Solid
color Dark Orange to Very Dark Orange
Safety Information
MSDS Information
Tafenoquine Usage And Synthesis
UsesTafenoquine is a pharmaceutical developed for the treatment of Plasmodium vivax malaria. Tafenoquine is also being explored for pharmaceutical use for inhibition of Toxoplasma gondii growth.
DefinitionChEBI: N(4)-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine is an aminoquinoline that is 8-aminoquinoline which is substituted by methoxy groups at positions 2 and 6, a methyl group at position 4, and a m-(trifluoromethyl)phenoxy group at position 5, and in which the amino substituent at position 8 is itself substituted by a 5-aminopentan-2-yl group. It is a member of (trifluoromethyl)benzenes, an aminoquinoline, an aromatic ether, a primary amino compound and a secondary amino compound.
Pharmaceutical ApplicationsEtaquine. A synthetic 8-aminoquinoline, formulated as the succinate for oral administration. Tafenoquine is an effective schizonticide against P. falciparum and P. vivax. It is also active against the pre-erythrocytic stages of these species and the hypnozoites of P. vivax. A dosage of 100 mg base corresponds to 125 mg salt. Oral absorption is slow with a maximum plasma concentration reached after 12 h. The half-life is 2 weeks, significantly longer than that of primaquine. It is not eliminated via the kidneys. Toxicity and side effects are similar to those of primaquine. Development of methemoglobinemia is common. Patients with G6PD deficiency may develop severe hemolysis.
It is in clinical development for the treatment and prophylaxis of P. vivax malaria and for the treatment of P. falciparum infection.
Tafenoquine Preparation Products And Raw materials
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