糠酸氟替卡松

糠酸氟替卡松

中文名称糠酸氟替卡松
中文同义词糠酸氟替卡松;氟替卡松糠酸酯;糠酸氟替卡松-[D3];5-二甲氧基-4-羟基甲苯;2H3]-糠酸氟替卡松;氟替卡松杂质31(糠酸氟替卡松)
英文名称FLUTICASONE FUROATE
英文同义词FLUTICASONE FUROATE;Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-17-((2- furanylcarbonyl)oxy)-11-hydroxy-16-methyl-3-oxo-, S-(fluoromethyl) ester, (6alpha,11beta,16alpha,17alpha)-;Gw 685698x;Unii-js86977wnv;Veramyst;(6α,11β,16α,17α)-6,9-Difluoro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-Methyl-3-oxoandrosta-1,4-diene-17-carbothioic Acid S-(FluoroMethyl) Ester;AllerMist;GSK 685 698
CAS号397864-44-7
分子式C27H29F3O6S
分子量538.58
EINECS号222-789-2
相关类别医药原料;原料药;医用原料;化工原料;皮质激素;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
Mol文件397864-44-7.mol
结构式糠酸氟替卡松 结构式

糠酸氟替卡松 性质

熔点250-252°C (dec.)
沸点625.2±55.0 °C(Predicted)
密度1.39
储存条件-20°C Freezer
溶解度可溶于氯仿(轻微、加热、超声处理)、甲醇(轻微)
酸度系数(pKa)12.52±0.70(Predicted)
形态固体
颜色白色至类白色

糠酸氟替卡松 用途与合成方法

糠酸氟替卡松为源自氟替卡松的一种人工合成皮质类固醇,可治疗过敏性鼻炎用。

糠酸氟替卡松(GW685698)是一种吸入性皮质类固醇/长效的β肾上腺素能受体激动剂的复方治疗药物,能延长支气管扩张剂的作用时间。它被用于非过敏性和过敏性皮炎的治疗。

Kd: 0.3 nM (Corticosteroid)

Fluticasone furoate comes in a nasal spray, as an aqueous suspension of micronized fluticasone furoate for topical administration to the nasal mucosa by means of a metering, atomizing spray pump.
Fluticasone furonate displays great potency in inhibiting tumor necrosis factor synthesis and action. Fluticasone furonate is also potent in preventing damage to cultured human lung epithelial cells by different stimulus.

Fluticasone furonate is 99.4% bound to plasma protein in vitro and other research indicated extensive first-pass metabolism of the absorbed drug. Protein binding is highly relevant because only the unbound free drug can exert an effect at the receptor site. Clearance of Fluticasone furonate is primarily by hydrolysis in the liver by the cytochrome P450 isozyme (CYP) 3A4 that converts the drug to the 17β-carboxylic acid metabolite (M10), which displays low glucocorticoid receptor agonist potency. Fluticasone furonate is excreted mainly in the feces, with only minor amounts in the urine.

安全信息

MSDS信息

更新日期产品编号产品名称CAS号包装价格
2024/04/30HY-15234Fluticasone furoate5 mg343元
2024/04/30HY-15234糠酸氟替卡松
Fluticasone furoate
397864-44-710mM * 1mLin DMSO610元

糠酸氟替卡松 上下游产品信息

"糠酸氟替卡松"相关产品信息
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