PHA-543613 Dihydrochloride 基本信息
| 中文名称 | PHA-543613 Dihydrochloride |
|---|---|
| 中文同义词 | |
| 英文名称 | PHA-543613 Dihydrochloride |
| 英文同义词 | PHA-543613 Dihydrochloride;N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxaMide Dihydrochloride;PHA 543613E;PHA-543613 Dihydrochloride DISCONTINUED |
| CAS号 | 478148-58-2 |
| 分子式 | C15H17N3O2 |
| 分子量 | 271.31438 |
| EINECS号 | |
| 相关类别 | Amines;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pfizer compounds;Pharmaceuticals |
| Mol文件 | 478148-58-2.mol |
| 结构式 |  |
PHA-543613 Dihydrochloride 性质
| 熔点 | >300?C |
|---|---|
| 储存条件 | Refrigerator |
| 溶解度 | 可溶于二甲基亚砜、甲醇 |
| 形态 | 固体 |
| 颜色 | 棕褐色 |
用途
PHA-543613 is a potent selective α7 nAChR agonist. Nicotinic acetylcholine receptors are ligand-gated ion channels activated by nicotine, expressed in multiple tissues, with high functional expression
in brain. The homomeric subtype α7 is a potential therapeutic target for cognitive deficits in schizophrenia and Alzheimer鈥瞫 disease. PHA-543613 is active in both in vitro (binding, calcium flux, pat
ch-clamp) and in vivo (auditory gating, novel object recognition) assays.