SR1001
| 中文名称 | SR1001 |
|---|---|
| 中文同义词 | 化合物SR1001;N-(5-(N-(4-(1,1,1,3,3,3-六氟-2-羟基丙烷-2-基)苯基)氨磺酰基)-4-甲基噻唑-2-基)乙酰胺;SR1001,RORΑ和RORΓT反向激动剂 |
| 英文名称 | SR 1001 |
| 英文同义词 | SR 1001;SR1001,N-{4-Methyl-5-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenylsulfaMoyl]-thiazol-2-yl}-acetaMide;N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulphamoyl)-4-methylthiazol-2-yl)acetamide;N-(5-{[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]sulfamoyl}-4-methyl-1,3-thiazol-2-yl)acetamide;N-[4-Methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolylacetamide;SR-1001;SR 1001;Acetamide, N-[4-methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolyl]-;SR1001 >=98% (HPLC) |
| CAS号 | 1335106-03-0 |
| 分子式 | C15H13F6N3O4S2 |
| 分子量 | 477.4 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1335106-03-0.mol |
| 结构式 |  |
SR1001 性质
| 密度 | 1.640±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Sealed in dry,2-8°C |
| 溶解度 | 二甲基亚砜：>5mg/mL |
| 酸度系数(pKa) | 5.90±0.50(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 稳定性 | 可在-20°下的DMSO中的溶液保存长达3个月。 |
| Target | Value |
|
RORγ
() | 111 nM(Ki) |
|
RORα
() | 172 nM(Ki) |
SR1001 inhibits the development of murine T H 17 cells by inhibition of IL-17A gene expression and protein production. SR1001 reduces the interaction of a coactivator TRAP220 NR box 2 peptide with ROR γ in a dose dependent manner (IC 50 value≈117 nM). Additionally, SR1001 inhibits the expression of cytokines when added to differentiated murine or human T H 17 cells.
SR1001 effectively suppresses the clinical severity of autoimmune disease in mice. Administration of SR1001 to C57BL/6 mice suppresses the expression of hepatic ROR target genes, Cyp7b1, Rev-erbα, and Serpine 1. SR1001 a ROR α inverse agonist eliminats the circadian pattern of expression of citrate synthase mRNA in mice.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-13421 | SR1001 | 1 mg | 304元 | |
| 2024/04/30 | HY-13421 | SR1001 SR1001 | 1335106-03-0 | 5mg | 760元 |