2,2' - ((((((亚甲基双(2-氯-4,1-亚苯基))二(氮烷二基))二(羰基))双(氮烷二
| 中文名称 | 2,2' - ((((((亚甲基双(2-氯-4,1-亚苯基))二(氮烷二基))二(羰基))双(氮烷二 |
|---|---|
| 中文同义词 | 2,2' - ((((((亚甲基双(2-氯-4,1-亚苯基))二(氮烷二基))二(羰基))双(氮烷二;2,2'-((((((亚甲基双(2-氯-4,1-亚苯基))二(氮烷二基))二(羰基))双(氮烷二基))二(4,1-亚苯基))二( 氧基))双(2-甲基丙酸);化合物LR-90;2,2' - ((((((亚甲基双(2-氯-4,1-亚苯基))二(氮烷二基))二(羰基))双(氮烷二 |
| 英文名称 | 2,2'-(4,4'-(4,4'-Methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxoMethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-Methylpropanoic acid) |
| 英文同义词 | 2,2'-(4,4'-(4,4'-Methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxoMethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-Methylpropanoic acid);2,2'-{Methylenebis[(2-chloro-4,1-phenylene)carbamoylimino-4,1-phenyleneoxy]}bis(2-methylpropanoic acid);2,2-[Methylenebis[(2-chloro-4,1-phenylene)iminocarbonylimino-4,1-phenyleneoxy]]bis[2-methylpropanoic acid];2,2'-((((((methylenebis(2-chloro-4,1-phenylene))bis(azanediyl))bis(carbonyl))bis(azanediyl))bis(4,1-phenylene))bis(oxy))bis(2-methylpropanoic acid);LR-90;Propanoic acid, 2,2'-[methylenebis[(2-chloro-4,1-phenylene)iminocarbonylimino-4,1-phenyleneoxy]]bis[2-methyl-;inhibit,Inhibitor,LR-90,LR90,LR 90;2,2'-(4,4'-(4,4'-Methylenebis(2-chloro-4,1-phenylene))bis(azanediyl)bis(oxoMethylene)bis(azanediyl)bis(4,1-phenylene))bis(oxy)bis(2-Methylpropanoic acid) |
| CAS号 | 245075-84-7 |
| 分子式 | C35H34Cl2N4O8 |
| 分子量 | 709.57 |
| EINECS号 | |
| 相关类别 | 生物活性分子-API |
| Mol文件 | 245075-84-7.mol |
| 结构式 |  |
2,2' - ((((((亚甲基双(2-氯-4,1-亚苯基))二(氮烷二基))二(羰基))双(氮烷二 性质
| 沸点 | 726.0±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.448±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：≥ 100 mg/mL (140.93 mM)；水：< 0.1 mg/mL（不溶） |
| 形态 | 固体 |
| 酸度系数(pKa) | 3.01±0.10(Predicted) |
| 颜色 | 白色至米白色 |
AGE
LR-90 (0, 25, 50, 100, and 200 μM) inhibits RAGE, MCP-1, COX-2, IP-10 and NOX2 mRNA expression in THP-1 cells in a dose-dependent manner, after pretreatment 1 h befor S100b stimulatation for 4 hours.
LR-90 (0, 25, 50, 100, and 200 μM) dose-dependently and significantly blocks THP-1 cells adherence to endothelial cells after pretreatment 1 h befor S100b stimulatation for 24 hours.
LR-90 (0, 25, 50, 100, and 200 μM, for 24 hours) shows no effect on the cell viability of THP-1 cells.
Cell Viability Assay
| Cell Line: | THP-1 cells |
| Concentration: | 0, 25, 50, 100, and 200 μM |
| Incubation Time: | 24 hours |
| Result: | Showed no cytotoxicity to THP-1 cells. |
RT-PCR
| Cell Line: | THP-1 cells |
| Concentration: | 0, 25, 50, 100, and 200 μM |
| Incubation Time: | One hour before S100b addition for 4 hours |
| Result: | Dose-dependently inhibited mRNA expression of RAGE, MCP-1, COX-2, IP-10, and NOX2 stimulated with S100b. |
LR-90 (50 mg/L, p.o. for 27 weeks) significantly reduces plasma lipids, modestly affects hyperglycaemia in ZDF rats.
LR-90 (50 mg/L) decreases renal AGE, AGER and lipid peroxidation.
| Animal Model: | Male ZDF rats (13 to 40 weeks) |
| Dosage: | 50 mg/L |
| Administration: | P.O. for 27 weeks |
| Result: | Significantly reduced plasma triacylglycerol and cholesterol by ∼55% and ∼30%, respectively. Modestly affected hyperglycaemia and blood pressure. Lowered the body weight. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-76383 | 2,2' - ((((((亚甲基双(2-氯-4,1-亚苯基))二(氮烷二基))二(羰基))双(氮烷二 LR-90 | 245075-84-7 | 5mg | 1800元 |
| 2024/04/30 | HY-76383 | 2,2' - ((((((亚甲基双(2-氯-4,1-亚苯基))二(氮烷二基))二(羰基))双(氮烷二 LR-90 | 245075-84-7 | 10mM * 1mLin DMSO | 2810元 |