|
Product Name: | ML167 | Synonyms: | ML167;ML167/ML-167;5-[4-[[(5-Methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol;CID 44968231;5-[4-[[(5-Methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-2-furanmethanol ML167;NCGC00188654;(5-(4-(((5-Methylfuran-2-yl)methyl)amino)quinazolin-6-yl)furan-2-yl)methanol;CID44968231;NCGC00188654 | CAS: | 1285702-20-6 | MF: | C19H17N3O3 | MW: | 335.36 | EINECS: | 808-432-9 | Product Categories: | Inhibitors | Mol File: | 1285702-20-6.mol | |
| ML167 Chemical Properties |
Boiling point | 531.8±45.0 °C(Predicted) | density | 1.335±0.06 g/cm3(Predicted) | storage temp. | -20°C | solubility | DMSO: soluble10mg/mL, clear | pka | 13.84±0.10(Predicted) | form | powder | color | off-white to gray to brown | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Hazard Codes | Xn | Risk Statements | 22 | Safety Statements | 46 | WGK Germany | 3 |
| ML167 Usage And Synthesis |
Description | ML167 (1285702-20-6) is a highly selective cell permeable inhibitor of Cdc2-like kinase 4 (Clk4) – IC50?= 136nM. It displays at least 10-fold greater selectivity over the related kinases Clk1(1.52 μM), Clk2(1.65μM), Clk3(>10μM), Dyrk1A(>10μM), and Dyrk1B(4.4 μM). | Definition | ChEBI: [5-[4-[(5-methyl-2-furanyl)methylamino]-6-quinazolinyl]-2-furanyl]methanol is a member of quinazolines. | target | Clk4 | References | 1) Rosenthal?et al. (2010),?An inhibitor of the Cdc2-like kinase 4 (Clk4); Probe Reports from the NIH Molecular Libraries Program |
| ML167 Preparation Products And Raw materials |
|