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Tipifarnib

Tipifarnib Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-(0)57185586718 +86-13336195806
Email: sales@capot.com
Products Intro: Product Name:Tipifarnib
CAS:192185-72-1
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:Tipifarnib
CAS:192185-72-1
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: sales@coreychem.com
Products Intro: Product Name:Tipifarnib
CAS:192185-72-1
Purity:99% Package:1kg;2USD
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Products Intro: Product Name:Tipifarnib
CAS:192185-72-1
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:tipifarnib
CAS:192185-72-1
Purity:0.99 Package:1kg

Tipifarnib manufacturers

  • Tipifarnib
  • Tipifarnib pictures
  • $34.00 / 1mg
  • 2024-11-19
  • CAS:192185-72-1
  • Min. Order:
  • Purity: 99.22%
  • Supply Ability: 10g
  • Tipifarnib
  • Tipifarnib pictures
  • $2.00 / 1kg
  • 2019-07-06
  • CAS:192185-72-1
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
Tipifarnib Basic information
Product Name:Tipifarnib
Synonyms:TIPIFARNIB;TIPIFARNIB ZARNESTRA;(R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone;Zarnestra;(R)-(+)-R 115777;6-[(R)-AMino(4-chlorophenyl)(1-Methyl-1H-iMidazol-5-yl)Methyl]-4-(3-chlorophenyl)-1-Methyl-2(1H)-quinolinone;Tipifarnib(Zarnestra,NSC-702818, R-115777);IND 58359
CAS:192185-72-1
MF:C27H22Cl2N4O
MW:489.4
EINECS:
Product Categories:Inhibitors;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Tyrosine Kinase Inhibitors;Inhibitor;Antineoplastic
Mol File:192185-72-1.mol
Tipifarnib Structure
Tipifarnib Chemical Properties
Melting point 211-213°C (dec.)
Boiling point 681.7±55.0 °C(Predicted)
density 1.33±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Chloroform (Slightly), Methanol (Slightly)
pka7.20±0.10(Predicted)
form powder
color white to beige
optical activity[α]/D 17 to 24°, c = 1 in methanol
Safety Information
HS Code 2933790090
MSDS Information
Tipifarnib Usage And Synthesis
Chemical PropertiesOff-White to Pale Beige Solid
UsesA farnesyltransferase inhibitor. Sensitizes human multiple myeloma cell to proteasome inhibition by blocking degradation of bortezomib(B675700)-induced aggresomes. Also shown to inhibit the growth of myeloid leukemia cell lines and primary leukemia cells by inducing apoptosis and cell-cycle blockage when combined with rapamycin(R124000).
DefinitionChEBI: Tipifarnib is a quinolone that is 1-methylquinolin-2-one which carries a 3-chlorophenyl and an amino(4-chlorophenyl)(1-methyl-imidazol-5-yl)methyl groups at the 4 and 6 positions, respectively (the R-isomer). It has a role as an antineoplastic agent, an EC 2.5.1.58 (protein farnesyltransferase) inhibitor and an apoptosis inducer. It is a quinolone, a member of monochlorobenzenes, a member of imidazoles and a primary amino compound.
General DescriptionPre-clinical studies show that tipifarnib has antiproliferative effects on pancreatic cancer cell lines at clinically relevant concentrations (concentration that inhibits 50% growth [IC50] from 9.5 to 500?nmol/L). It also exhibits marked growth retardation and antiangiogenic effects in a pancreatic cancer xenograft model.
Biological Activitytipifarnib (also known as zarnestra or r115777), an orally bioavailable quinolone analog of imidazole heterocyclics, is a potent and specific nonpeptidomimetic competitive inhibitor of farnesyltransferase (ftase), an enezyme mediating post-translational farnesylation of multiple protein substrates involved in tumor cell proliferation. it has demonstrated inhibition of growth and proliferation of a broad range of human tumor models (either wild-type or mutated ras) via cytostatic rather than cytotoxic activity both in vitro and in vivo. it cell-type dependently induces apoptosis in some neoplastic cell lineages other than acute myeloid leukemia (aml), including multiple myeloma (mm) cell lines and mm cultures from patients.p.k. epling-burnett and thomas p. loughran jr. suppression of farnesyltransferase activity in acute myeloid leukemia and myelodysplastic syndrome: current understanding and recommended use of tipifarnib. expert opin investig drugs. 2010; 19(5): 689-698jean-pierre armand, alan k. burnett, johannes drach, jean-luc harousseau, bob lowenberg and jesus san miguel. the emerging role of targeted therapy for hematologic malignancies: update on bortezomib and tipifarnib. the oncologist 2007, 12:281-290elzbieta izbicka, david campos, gilbert carrizales and amita patnaik. biomarkers of anticancer activity of r115777 (tipifarnib, zarnestra) in human breast cancer models in vitro. anticancer research 2005; 25: 3215-3224
Biochem/physiol ActionsTipifarnib (R115777) is an orally active and potent farnesyltransferase (FTase) inhibitor that exhibits potent anti-tumorigenic effects. Tipifarnib mechanism of action is not fully understand.
targetFTase
Tipifarnib Preparation Products And Raw materials
Tag:Tipifarnib(192185-72-1) Related Product Information
Glucosamine Levamisole Methylparaben Sulfamic acid Thiophanate-methyl Bensulfuron methyl Methyl acrylate EC 2.6.1.2 Methyl acetate Imidazole FARNESOL Acetaminophen Kresoxim-methyl Methyl FARNESENE (MIXTURE OF ISOMERS)[FOR PERFUMERY] Phenylacetone Methyl bromide Parathion-methyl