溴夫定
中文名称 | 溴夫定 |
---|---|
中文同义词 | 溴夫定;溴乙烯尿苷;5-[(E)-2-溴乙烯基]-1-[(2R,4S,5R)-4-羟基-5-(羟甲基)氧杂环戊-2-基]嘧啶-2,4-二酮;溴呋啶;溴夫定(标准品);溴夫啶;(E)-5-(2-溴乙烯基)-2'-脱氧核苷;溴比夫定 |
英文名称 | Brivudine |
英文同义词 | Helpin;Uridine,5-[(1E)-2-broMoethenyl]-2'-deoxy-;(E)-(5)-BROMOVINYL-2-DEOXYURIDINE;(E)-5-(2-Bromovinyl)-2'-deoxyuridine;BVDU;(E)-5-(2-BROMOVINYL)-2'-DEOXY-URIDINE;BRIVUDINE;5-(E)-(2-Bromovinyl)-2-deoxyuridine |
CAS号 | 69304-47-8 |
分子式 | C11H13BrN2O5 |
分子量 | 333.14 |
EINECS号 | 1806241-263-5 |
相关类别 | 合成;医药原料药;医药中间体;小分子抑制剂;小分子抑制剂,天然产物;其他科研原料药;API;Inhibitors |
Mol文件 | 69304-47-8.mol |
结构式 |
溴夫定 性质
熔点 | 165°C |
---|---|
密度 | 1.7800 (rough estimate) |
折射率 | 1.6520 (estimate) |
储存条件 | Inert atmosphere,2-8°C |
溶解度 | 可溶于DMSO(少许)、甲醇(少许) |
形态 | 固体 |
酸度系数(pKa) | 8.37±0.10(Predicted) |
颜色 | 米白色 |
水溶解性 | Soluble in water and methanol. |
Merck | 14,1378 |
InChIKey | ODZBBRURCPAEIQ-CXYVBZRVSA-N |
Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage.
At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia.
安全信息
安全说明 | 24/25 |
---|---|
WGK Germany | 3 |
RTECS号 | YU7355000 |
海关编码 | 29349990 |
提供商 | 语言 |
---|---|
英文
|
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | H27853 | (E)-5-(2-溴乙烯基)-2'-脱氧核苷, 98% (E)-5-(2-Bromovinyl)-2'-deoxyuridine, 98% | 69304-47-8 | 50mg | 793元 |
2024/08/19 | H27853 | (E)-5-(2-溴乙烯基)-2'-脱氧核苷, 98% (E)-5-(2-Bromovinyl)-2'-deoxyuridine, 98% | 69304-47-8 | 250mg | 2439元 |