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| | 2'-Hydroxy-5'-methoxyacetophenone Basic information |
| | 2'-Hydroxy-5'-methoxyacetophenone Chemical Properties |
| Melting point | 52 °C(lit.) | | Boiling point | 254.38°C (rough estimate) | | density | 1.1708 (rough estimate) | | refractive index | 1.5500 (estimate) | | Fp | >230 °F | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | pka | 10.65±0.18(Predicted) | | form | Crystalline Powder | | color | Yellow | | Odor | Aromatic, somewhat medicinal, warm, woody -the herbaceous odour of good tenacity. | | BRN | 1239364 | | InChIKey | MLIBGOFSXXWRIY-UHFFFAOYSA-N | | CAS DataBase Reference | 705-15-7(CAS DataBase Reference) | | NIST Chemistry Reference | Ethanone, 1-(2-hydroxy-5-methoxyphenyl)-(705-15-7) |
| | 2'-Hydroxy-5'-methoxyacetophenone Usage And Synthesis |
| Chemical Properties | yellow crystalline powder | | Uses | 2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols. 2-Hydroxy-5-methoxyacetophenone is also used to prepare substituted chromanone and chromone derivatives as sirtuin 2-selective inhibitors. | | Preparation | reparation by reaction of dimethyl sulfate on 2,5-dihydroxyacetophenone, ? with potassium carbonate in acetone at r.t. (74%) ; ? with aqueous sodium hydroxide solution at reflux (35%). | | Application |
2'-Hydroxy-5'-methoxyacetophenone could find some use in perfume compositions, e. g., in artificial Oakmoss, in New Mown Hay fragrances, and in certain heavy florals. It blends well with Labdanum and with Lavender type oils, and it lends a certain amount of power and undertones to the fragrance.
| | Synthesis Reference(s) | Synthesis, p. 901, 1985 DOI: 10.1055/s-1985-31380 | | General Description | 2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols. |
| | 2'-Hydroxy-5'-methoxyacetophenone Preparation Products And Raw materials |
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