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| | TOMEGLOVIR Basic information |
| Product Name: | TOMEGLOVIR | | Synonyms: | TOMEGLOVIR;N-[4-[[[5-(Dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methylpropanamide;BAY 38-4766;Tomeglovir (BAY-38-4766);Propanamide, N-[4-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methyl-;tomeglovir cas | | CAS: | 233254-24-5 | | MF: | C23H27N3O4S | | MW: | 441.54 | | EINECS: | | | Product Categories: | | | Mol File: | 233254-24-5.mol |  |
| | TOMEGLOVIR Chemical Properties |
| density | 1.334±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 108 mg/mL (244.60 mM) | | form | Solid | | pka | 8.96±0.50(Predicted) | | color | Light yellow to yellow |
| | TOMEGLOVIR Usage And Synthesis |
| Biological Activity | Tomeglovir is an anti-CMV agent that inhibits the progression of viral DNA concatemers with IC50 values of 0.34 μM and 0.039 μM for HCMV and MCMV, respectively. | | in vitro | Tomeglovir (BAY 38-4766) is a potent anti-CMV agent, with IC 50 s of 0.34 μM and 0.039 μM for HCMV and MCMV. Tomeglovir also suppresses HELF and NIH 3T3 cells, with CC 50 s of 85 μM and 62.5 μM, respectively. Tomeglovir (BAY 38-4766) inhibits HCMV Davis and various monkey CMV strains with EC 50 s of 1.03 ± 0.57 μM and < 1 μM. | | in vivo | Tomeglovir (BAY 38-4766; 3, 10, 30, 100 mg/kg, po) dose-dependently reduces MCMV-DNA in salivary glands, livers and kidneys of MCMV-infected NOD-SCID mice, and prolongs the survival of the mice. It (10, 25 and 50 mg/kg) shows antiviral activity in the hollow fiber mouse model. Tomeglovir (BAY 38-4766) shows antiviral activity in SCID mice with MCMV, and the LD 50 is >2000 mg/kg in mice and rats. | | target | IC50: 0.34 μM (HCMV), 0.039 μM (MCMV) |
| | TOMEGLOVIR Preparation Products And Raw materials |
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