托美洛韦
| 中文名称 | 托美洛韦 |
|---|---|
| 中文同义词 | 托美洛韦 |
| 英文名称 | TOMEGLOVIR |
| 英文同义词 | TOMEGLOVIR;N-[4-[[[5-(Dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methylpropanamide;BAY 38-4766;Tomeglovir (BAY-38-4766);Propanamide, N-[4-[[[5-(dimethylamino)-1-naphthalenyl]sulfonyl]amino]phenyl]-2-(hydroxymethyl)-2-methyl-;tomeglovir cas |
| CAS号 | 233254-24-5 |
| 分子式 | C23H27N3O4S |
| 分子量 | 441.54 |
| EINECS号 | |
| 相关类别 | 原料药 API |
| Mol文件 | 233254-24-5.mol |
| 结构式 |  |
托美洛韦 性质
| 密度 | 1.334±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥ 108 mg/mL（244.60 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 8.96±0.50(Predicted) |
| 颜色 | 浅黄至黄色 |
IC50: 0.34 μM (HCMV), 0.039 μM (MCMV)
Tomeglovir (BAY 38-4766) is a potent anti-CMV agent, with IC 50 s of 0.34 μM and 0.039 μM for HCMV and MCMV. Tomeglovir also suppresses HELF and NIH 3T3 cells, with CC 50 s of 85 μM and 62.5 μM, respectively. Tomeglovir (BAY 38-4766) inhibits HCMV Davis and various monkey CMV strains with EC 50 s of 1.03 ± 0.57 μM and < 1 μM.
Tomeglovir (BAY 38-4766; 3, 10, 30, 100 mg/kg, p.o.) dose-dependently reduces MCMV-DNA in salivary glands, livers and kidneys of MCMV-infected NOD-SCID mice, and prolongs the survival of the mice. Tomeglovir (10, 25 and 50 mg/kg) shows antiviral activity in the hollow fiber mouse model. Tomeglovir (BAY 38-4766) shows antiviral activity in SCID mice with MCMV, and the LD 50 is >2000 mg/kg in mice and rats.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-108261 | 托美洛韦 Tomeglovir | 233254-24-5 | 5mg | 1100元 |
| 2024/08/19 | HY-108261 | 托美洛韦 Tomeglovir | 233254-24-5 | 10mM * 1mLin DMSO | 1210元 |