3a-羟基-5b-雄甾烷-17-酮
中文名称 | 3a-羟基-5b-雄甾烷-17-酮 |
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中文同义词 | 还原尿睾酮 溶液;5Β-雄酮;还原胆烷醇酮;还原尿睾酮;苯胆烷醇酮;3a-羟基-5b-雄甾烷-17-酮;还原尿睾酮/还原胆烷醇酮;5Β-雄甾-3Α-醇-17-酮(本胆烷醇酮) |
英文名称 | Etiocholanone |
英文同义词 | 3α-Etiocholanolone;3α-Hydroxy-5β-androstane-17-one;5β-Androstane-3α-ol-17-one;5β-Androstero;5-Androstan-3a-ol-17-one-d2;5β-Androsterone;3alpha-Hydroxyetiocholan-17-one;C04373 |
CAS号 | 53-42-9 |
分子式 | C19H30O2 |
分子量 | 290.44 |
EINECS号 | 200-835-2 |
相关类别 | Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroids & Hormones - 13C & 2H;Steroids |
Mol文件 | 53-42-9.mol |
结构式 |
3a-羟基-5b-雄甾烷-17-酮 性质
熔点 | 148~150℃ |
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沸点 | 392.52°C (rough estimate) |
密度 | 0.9731 (rough estimate) |
折射率 | 1.5360 (estimate) |
闪点 | 2℃ |
储存条件 | room temp |
溶解度 | 二甲基亚砜:100 mg/mL(344.31 mM) |
形态 | 固体 |
酸度系数(pKa) | 15.14±0.60(Predicted) |
颜色 | 白色至米白色 |
水溶解性 | 20.33mg/L(25 ºC) |
BRN | 2217625 |
CAS 数据库 | 53-42-9(CAS DataBase Reference) |
NIST化学物质信息 | Androstan-17-one, 3-hydroxy-, (3«alpha»,5«beta»)-(53-42-9) |
Etiocholanolone (10 μM) coapplication with GABA leads to an increase in the relative frequency of long openings (fraction of OT3, site A2 effect), but it is ineffective at increasing the duration of long openings (site B effect) or at decreasing the relative frequency of the activation-related closed time component (site A1 effect).
Etiocholanolone (intraperitoneal injection; 0-109.1 mg/kg; single dose) exhibits ED50 values of 57.6 and 109.1 mg/kg in the 6-Hz and PTZ tests, respectively. Protective activity in the 6-Hz test of 5β,3α-A persists for 2 h and is shorter than ent-5β,3α-A treatment (3 hours) in mice.
安全信息
危险品标志 | F,Xn |
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危险类别码 | 11-20/21/22-36 |
安全说明 | 16-36/37 |
危险品运输编号 | UN 1648 3 / PGII |
WGK Germany | 3 |
提供商 | 语言 |
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英文
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