艾美拉唑钾盐
中文名称 | 艾美拉唑钾盐 |
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中文同义词 | 埃索美拉唑钾;埃索拉唑钾盐;6-甲氧基-2-[(S)-[(4-甲氧基-3,5-二甲基-2-吡啶基)甲基]亚磺酰基]-1H-苯并咪唑钾盐;6-甲氧基-2-[(S)-[(4-甲氧基-3,5-二甲基-2-吡啶基)甲基]亚磺酰基]-1H-苯并咪唑钾盐 (1:1);艾美拉唑钾盐;埃索美拉唑钾盐;化合物 ESOMEPRAZOLE POTASSIUM SALT |
英文名称 | Esomeprazole potassium |
英文同义词 | (S)-Omeprazole potassium;6-Methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole potassium salt (1:1);Esomeprazole potassium;(R)-5-METHOXY-2-((4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYLSULFINYL)BENZO[D]IMIDAZOL-1-IDE POTASSIUM SALT;(S)-5-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzo[d];potassium,5-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide;1H-Benzimidazole,6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-,potassium salt (1:1);Esomeprazole potassium USP/EP/BP |
CAS号 | 161796-84-5 |
分子式 | C17H20KN3O3S |
分子量 | 385.52 |
EINECS号 | 449-880-1 |
相关类别 | 医药原料药;医用原料;原料药 |
Mol文件 | 161796-84-5.mol |
结构式 |
艾美拉唑钾盐 性质
蒸气压 | 0Pa at 25℃ |
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储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
形态 | 固体 |
颜色 | 白色至米白色 |
H + , K + -ATPase
Esomeprazole (25-100 µM; 20 hours; MDA-MB-468 cells) treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification.
Cell Viability Assay
Cell Line: | MDA-MB-468 cells |
Concentration: | 25 µM, 50 µM, 75 µM, 100 µM |
Incubation Time: | 20 hours |
Result: | Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner. |
Esomeprazole (30-300 mg/kg; oral gavage; daily; for 19 or 11 days; C57BL/6J mice) treatment significantly inhibits the progression of fibrosis throughout the lungs of the animals. Esomeprazole also reduces circulating markers of inflammation and fibrosis.
Animal Model: | C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury |
Dosage: | 30 mg/kg, 300 mg/kg |
Administration: | Oral gavage; daily; for 19 or 11 days |
Result: | Significantly inhibited the progression of fibrosis throughout the lungs of the animals. |