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Orciprenaline sulfate

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Products Intro: Product Name:Orciprenaline sulfate
CAS:5874-97-5
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CAS:5874-97-5
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Products Intro: Product Name:Metaproterenol hemisulfate;Metaproterenol Sulfate;Orciprenaline sulfate
CAS:5874-97-5
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CAS:5874-97-5
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CAS:5874-97-5
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Orciprenaline sulfate manufacturers

  • Orciprenaline sulfate
  • Orciprenaline sulfate pictures
  • $8.80 / 1KG
  • 2019-07-06
  • CAS:5874-97-5
  • Min. Order: 1KG
  • Purity: 97%-99%
  • Supply Ability: 100kg
Orciprenaline sulfate Basic information
Product Name:Orciprenaline sulfate
Synonyms:1-(3,5-dihydroxyphenyl)-1-hydroxy-2-isopropylaminoethanesulfate;1-(3,5-dihydroxyphenyl)-2-(isopropylamino)ethanolsulfate;3,5-dihydroxy-alpha-((isopropylamino)methyl)benzylalcoholsulfate;3,5-dihydroxy-alpha-((isopropylamino)methyl)-benzylalcohosulfate(2:1)(s;3-benzenediol,5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-sulfate(2:1);alotec;metaprel;novasmasol
CAS:5874-97-5
MF:C22H36N2O10S
MW:520.59
EINECS:227-539-6
Product Categories:Adrenergics;Agonists;Neurotransmitters;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;5874-97-5
Mol File:5874-97-5.mol
Orciprenaline sulfate Structure
Orciprenaline sulfate Chemical Properties
Melting point 202-203°
storage temp. 2-8°C
solubility Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
form Solid
color White to Off-White
Stability:Hygroscopic
Safety Information
Hazard Codes Xn
Risk Statements 20
Safety Statements 36
WGK Germany 2
RTECS DO2275000
HS Code 2922504500
ToxicityLD50 in rats (mg/kg): 42 orally (Goldenthal)
MSDS Information
ProviderLanguage
SigmaAldrich English
Orciprenaline sulfate Usage And Synthesis
Chemical PropertiesWhite or almost white, slightly hygroscopic, crystalline powder.
OriginatorAlupent, Boehringer Ingelheim ,W. Germany ,1961
UsesBronchodilatator;Beta-adrenergic agonist
UsesBeta2-adrenoceptor agonist; bronchodilator.
Manufacturing ProcessIn an initial operation, 3,5-diacetoxyacetophenone was reacted first with bromine and then with isopropylamine to give 1-(3,5-dihydroxyphenyl)-2- isopropylaminoethanone.
59 g of 1-(3,5-dihydroxy-phenyl)-2-isopropylaminoethanone (free base) were dissolved in 590 cc of methanol, and the solution was hydrogenated in the presence of about 80 g Raney nickel at room temperature and under a pressure of 5 atm. Hydrogen absorption was terminated after a few minutes. The catalyst was separated by vacuum filtration, and the filtrate, an ethanolic solution of 1-(3,5-dihydroxyphenyl)-1-hydroxy-2-isopropylaminoethane, was admixed with the calculated amount of an alcoholic 20% sulfuric acid solution. A crystalline precipitate formed which was filtered off and washed with alcohol. For purification, the product was dissolved in water and the solution was filtered through iron-free charcoal.
Thereafter, the filtrate was evaporated to dryness in vacuo and the residue was taken up in alcohol. The crystalline precipitate which separated out after some standing was separated by vacuum filtration and washed with alcohol. After recrystallization from 90% alcohol, 61 g (83.2% of theory) of 1-(3,5- dihydroxyphenyl)-1-hydroxy-2-isopropylamino-ethane sulfate, MP 202° to 203°C, was obtained.
Brand nameAlupent (Boehringer Ingelheim); Prometa (Muro).
Therapeutic FunctionBronchodilator
PharmacokineticsMetaproterenol is a direct-acting resorcinol analogue of isoproterenol. The N-isopropyl is β-directing, and the combination with the resorcinol ring system enhances the selectivity for the β2-receptors. It is the least potent of the β2-selective agonists, however, most likely because of the poor β2-selectivity of the isopropyl group. It has good oral bioavailability being resistant to COMT and only slowly metabolized by MAO. When administered orally, it has an onset of approximately 30 minutes with a 4-hour duration. Inhaled metaproterenol can have an onset as quick as 5 minutes; however, it can be as long as 30 minutes in susceptible individuals. Metaproterenol is available in tablet, syrup, and inhalation dosage forms and is recommended for bronchial asthma attacks and treatment of acute asthmatic attacks in children 6 years of age and older (5% solution for inhalation only). Metaproterenol has the same adverse effect profile as other adrenergic agonists, but with a decreased incidence of arrhythmias.
Orciprenaline sulfate Preparation Products And Raw materials
Raw materialsIsopropylamine-->Hydrogen
Tag:Orciprenaline sulfate(5874-97-5) Related Product Information
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