| Company Name: |
Lynnchem
|
| Tel: |
86-(0)29-85992781 17792393971 |
| Email: |
info@lynnchem.com |
| Products Intro: |
Product Name:KIGAMICIN C
CAS:680571-51-1
Purity:>98% by HPLC Package:1mg;5mg
|
| Company Name: |
Novachemistry
|
| Tel: |
44-20819178-90 02081917890 |
| Email: |
info@novachemistry.com |
| Products Intro: |
Product Name:Kigamicin C
CAS:680571-51-1
Purity:>98% by HPLC Package:1mg;5mg
|
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| | KIGAMICIN C Basic information |
| Product Name: | KIGAMICIN C | | Synonyms: | KIGAMICIN C;Oxazolo[3,2-b]xantheno[4',3',2':4,5][1,3]benzodioxino[7,6-g]isoquinoline-16,19-dione, 3-[[(2S,5S,6R)-5-[(2,6-dideoxy-3-O-methyl-β-D-arabino-hexopyranosyl)oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-1,2,3,4,8a,9,11,11a,13,14-decahydro-1,4,17,18-tetrahydroxy-11a-methyl-, (1S,3R,4S,8aR,11aR)- | | CAS: | 680571-51-1 | | MF: | C41H47NO16 | | MW: | 809.81 | | EINECS: | | | Product Categories: | | | Mol File: | 680571-51-1.mol |  |
| | KIGAMICIN C Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | | form | Yellow powder. |
| | KIGAMICIN C Usage And Synthesis |
| Uses | Kigamicin C is a novel antibiotic antiproliferative with novel action. | | Uses | Kigamicin C was discovered by an anti-austerity strategy, targeting cancer cells' tolerance to starvation. It selectively kills PANC-1 cells (a pancreatic cell line) at concentrations 100 times lower under nutrient starved conditions than in normal conditions. The mechanism of action is proposed to be via blockade of aPKB/Akt activation, caused by the withdrawal of nutrients. It is active in vivo against a human pancreatic cancer xenograft model. Kigamicin C also inhibits the growth of Gram positive bacteria including MRSA, but is not active against Gram negative bacteria. |
| | KIGAMICIN C Preparation Products And Raw materials |
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