β-淀粉样蛋白(31-35)
中文名称 | β-淀粉样蛋白(31-35) |
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中文同义词 | 异亮氨酰-异亮氨酰-甘氨酰-亮氨酰-蛋氨酸;AMYLOID Β肽(31-35);淀粉样肽 AMYLOID Β-PROTEIN (31-35);Β-淀粉样蛋白(31-35) |
英文名称 | H-ILE-ILE-GLY-LEU-MET-OH |
英文同义词 | Isoleucinyl-isoleucinyl-glycinyl-leucinyl-methionine;AMyloid b-Protein (31-35);AMYLOID BETA-PROTEIN (31-35);AMYLOID-BETA PROTEIN (31-35), HUMAN, MOUSE, RAT;BETA-AMYLOID (31-35);IIGLM;ILE-ILE-GLY-LEU-MET;H-ILE-ILE-GLY-LEU-MET-OH |
CAS号 | 149385-65-9 |
分子式 | C25H47N5O6S |
分子量 | 545.74 |
EINECS号 | |
相关类别 | 多肽;目录多肽;peptide |
Mol文件 | 149385-65-9.mol |
结构式 | ![]() |
β-淀粉样蛋白(31-35) 性质
沸点 | 866.4±65.0 °C(Predicted) |
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密度 | 1.137±0.06 g/cm3(Predicted) |
储存条件 | −20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 3.24±0.10(Predicted) |
形态 | 固体 |
颜色 | 白色至米白色 |
序列 | H-Ile-Ile-Gly-Leu-Met-OH |
β-Amyloid (31-35) is a functional cytotoxic domain of Aβ peptide. β-Amyloid (31-35) increases the phosphorylation of biotinylated Aβ(1-40), enhances CDK-1 activity, and also inhibits binding of Aβ to cyclin B1. β-Amyloid (31-35) is cytotoxic, and such an effect can be inhibited by olomoucine in differentiated human teratocarcinoma cell line, Ntera 2/cl-D1 (NT-2) neurons.
β-Amyloid Aggregation Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization and randomization of structure.
2. The HFIP was removed by evaporation, and the resulting peptide was stored as a film at -20 or -80 °C.
3. The resulting film was dissolved in anhydrous DMSO at 5 mM and then diluted into the appropriate concentration and buffer (serum- and phenol red-free culture medium) with vortexing.
4. Next, the solution was age 48h at 4-8 °C. The sample was then centrifuged at 14000g for 10 min at 4-8 °C; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments.
Methods vary depends on the downstream applications.
纯度(HPLC) ≥98.0%
醋酸根含量5.0%~12.0%
水分含量≤8.0%
肽含量≥80.0%
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-P1517 | 异亮氨酰-异亮氨酰-甘氨酰-亮氨酰-蛋氨酸 β-Amyloid (31-35) | 149385-65-9 | 1mg | 700元 |
2024/08/19 | HY-P1517 | 异亮氨酰-异亮氨酰-甘氨酰-亮氨酰-蛋氨酸 β-Amyloid (31-35) | 149385-65-9 | 5mg | 1400元 |