N-氧代烟酰胺
中文名称 | N-氧代烟酰胺 |
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中文同义词 | N-氧化烟酰胺;烟碱-N-氧化物;N-氧代烟酰胺;烟酰胺-N-氧化物;烟酰胺氮氧化物;烟碱-N-氧化物,98%;烟酰胺-N-氧化物 N-氧代烟酰胺;尼克酰胺N氧化物 |
英文名称 | Nicotinamide-N-oxide |
英文同义词 | 1-OXY-NICOTINAMIDE;3-(AMINOCARBONYL)PYRIDINIUM-1-OLATE;AKOS 94294;NICOTINAMIDE 1-OXIDE;NICOTINAMIDE N-OXIDE;TIMTEC-BB SBB004187;3-Pyridinecarboxamide, 1-oxide;3-Pyridinecarboxamide,1-oxide(9CI) |
CAS号 | 1986-81-8 |
分子式 | C6H6N2O2 |
分子量 | 138.12 |
EINECS号 | 217-859-4 |
相关类别 | 生化试剂;医药中间体;核苷,核苷酸,寡核苷酸;小分子抑制剂;无机化工原料;其他原料;有机中间体;生化试剂-维生素;有机化工原料;杂质对照品;合成材料中间体;Amines, Heterocycles, Metabolites & Impurities, Nicotine Derivatives, Nucleotides, Bases & Related Reagents;Amines;AMIDE;Biochemicals and Reagents;NAD and Analogs;Nucleosides, Nucleotides, Oligonucleotides;Bases & Related Reagents;Heterocycles;Metabolites & Impurities;Nicotine Derivatives;Nucleotides |
Mol文件 | 1986-81-8.mol |
结构式 | ![]() |
N-氧代烟酰胺 性质
熔点 | 291-293 °C (dec.)(lit.) |
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沸点 | 253.51°C (rough estimate) |
密度 | 1.3471 (rough estimate) |
折射率 | 1.5100 (estimate) |
储存条件 | Inert atmosphere,Room Temperature |
溶解度 | 可溶于DMSO(略微加热)、甲醇(略微加热) |
形态 | 固体 |
酸度系数(pKa) | 14.38±0.50(Predicted) |
颜色 | 白色至类白色 |
敏感性 | Hygroscopic |
CAS 数据库 | 1986-81-8(CAS DataBase Reference) |
CXCR2
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Human Endogenous Metabolite
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Nicotinamide is one of the forms of vitamin B 3 . It is a precursor for nicotinamide adenine dinucleotide, which is best known as an electron carrier in oxidative phosphorylation and as a cofactor for many dehydrogenases. It is metabolized through two enzymatic systems. The first system starts with the methylation of nicotinamide by nicotinamide N-methyltransferase, which can subsequently be oxidized by aldehyde oxidase. The second enzymatic system oxidizes nicotinamide to nicotinamide N-oxide. A series of nicotinamide N-oxides is synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Compound 1 has demonstrated potent inhibition of neutrophil chemotaxis (IC 50 =10 nM). Compound 2 is a selective antagonist of IL-8 binding (IC 50 =110 nM) and potent inhibitor of neutrophil chemotaxis (IC 50 =170 nM).
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