|
|
| | Zindotrine Basic information |
| Product Name: | Zindotrine | | Synonyms: | 8-methyl-6-piperidin-1-yl-[1,2,4]triazolo[3,4-f]pyridazine;8-methyl-6-piperidino-[1,2,4]triazolo[3,4-f]pyridazine;Zindotrine;1,2,4-Triazolo[4,3-b]pyridazine, 8-methyl-6-(1-piperidinyl)- | | CAS: | 56383-05-2 | | MF: | C11H15N5 | | MW: | 217.27 | | EINECS: | | | Product Categories: | | | Mol File: | 56383-05-2.mol |  |
| | Zindotrine Chemical Properties |
| density | 1.36±0.1 g/cm3(Predicted) | | pka | 4.80±0.30(Predicted) |
| | Zindotrine Usage And Synthesis |
| Originator | Zindotrine,Dow Chemical Co., USA | | Uses | Bronchodilator. | | Manufacturing Process | A mixture of 20.0 g of 3-hydrazino-4-methyl-6-piperidinopyridazine in 100 ml
of aqueous 99% formic acid was heated at the boiling temperature under
reflux for 3 h and then evaporated to dryness. The residue, containing 8-
methyl-6-piperidino-s-triazolo[4,3-b]pyridazine formate was taken up in
excess aqueous sodium carbonate and extracted with chloroform. After
evaporation of the chloroform solvent the 8-methyl-6-piperidino-s-
triazolo[4,3-b]pyridazine was crystallized from ethyl acetate. Yield 4.4 g,
melting point 118-120°C. | | Therapeutic Function | Bronchodilator |
| | Zindotrine Preparation Products And Raw materials |
|