3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Suppliers list

Company Name:	Changzhou uniringchem Co., Ltd.
Tel:	+undefined13585446801
Email:	sales@uniringchem.com
Products Intro:	Product Name:4-Amino-3-iodopyrazolo[3,4-d]pyrimidine CAS:151266-23-8 Purity:0.98 Package:500kg,100kg,5KG;1KG

Company Name:	Taizhou Creating Bio-pharm co., ltd.
Tel:	+8613586099526
Email:	post@creatingbiopharm.com
Products Intro:	Product Name:3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine CAS:151266-23-8 Purity:0.99 Package:1G；100G;1KG

Company Name:	Lianhe Aigen Pharmatech Co.,Ltd.
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Products Intro:	Product Name:3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine CAS:151266-23-8 Purity:1G, 5G, 10G, 50G,100G Package:98%

Company Name:	Henan Fengda Chemical Co., Ltd
Tel:	+86-371-86557731 +86-13613820652
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Products Intro:	Product Name: 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine CAS:151266-23-8 Purity:98% Package:1KG;5USD\|1000KG;0.1USD

Company Name:	Shaanxi Xianhe Biotech Co., Ltd
Tel:	+8617709210191
Email:	Jerry@xhobio.com
Products Intro:	Product Name:3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine CAS:151266-23-8 Purity:0.99 Package:1kg;0.00;USD

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine manufacturers

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Basic information

Product Name:	3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Synonyms:	3-iodo-2H-pyrazolo[3,4-d]pyrimidin-4-amine;3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE;4-AMINO-3-IODO-1H-PYRAZOLO[3,4-D]PYRIMIDINE;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-iodo-;4-Amino-3-iodo-1H-pyrazolo[3,4-D]pyridine;3-iodo-4-AMino-1H-pyrazolo[3,4-d]pyridine;7-Iodo-7-deaza-8-aza-adenine;3-iodopyrazolo[3,4-d]pyriMidin-4-aMine
CAS:	151266-23-8
MF:	C5H4IN5
MW:	261.02
EINECS:
Product Categories:	Heterocycle-Pyridine series;pharmacetical
Mol File:	151266-23-8.mol

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Chemical Properties

Boiling point	312.3±52.0 °C(Predicted)
density	2.92±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	powder to crystal
pka	10.50±0.20(Predicted)
color	White to Light yellow to Light orange
Sensitive	Light Sensitive
λmax	282nm(lit.)
InChI	InChI=1S/C5H4IN5/c6-3-2-4(7)8-1-9-5(2)11-10-3/h1H,(H3,7,8,9,10,11)
InChIKey	HQAIUXZORKJOJY-UHFFFAOYSA-N
SMILES	C1=NC(N)=C2C(I)=NNC2=N1

Safety Information

MSDS Information

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Usage And Synthesis

Uses	3-Iodo-3H-pyrazolo[3,4-d]pyrimidin-4-amine acts as a reagent in the discovery and preparation of CHMFL-FLT3-122 as potent and orally available FLT3 kinase inhibitor for FLT3-ITD positive acute myeloid leukemia. Development and preparation of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.
Synthesis	A solution of 3H-pyrazolo[3,4-d]pyrimidin-4-amine (10 g, 0.074 mol) and n-iodo-succinamide (25 g, 0.111 mol) in DMF (80 mL) was heated to 80° C. overnight under an argon atmosphere. The resulting solid was filtered and rinsed with cold EtOH. The product was dried in vacuo overnight to yield 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine (24 g, 100 per cent yield).

3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine Preparation Products And Raw materials

Raw materials	4-Chloro-1H-pyrazolo[3,4-d]pyrimidine-->4-Aminopyrazolo[3,4-d]pyrimidine-->2H-Pyrazolo[3,4-d]pyrimidin-4-amine (9CI)-->N-Iodosuccinimide
Preparation Products	(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine-->1-cyclopentyl-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine-->3-(4-Phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine

Tag:3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine(151266-23-8) Related Product Information

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