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ChemicalBook > Product Catalog >Organic Chemistry >Nitrogen Compounds >4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

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4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Suppliers list
Company Name: Shanghai Minbiotech Co., Ltd.
Tel: +8617315815539
Email: sales@minbiotech.com
Products Intro: Product Name:4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE
CAS:479633-63-1
Purity:99% HPLC Package:1g；1kg；10kg
Company Name: Huanfu Industrial Co.，（Shanghai）Ltd.
Tel: +86-18001856580 +86-18001856580
Email: 2415195517@qq.com
Products Intro: Product Name:4-chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
CAS:479633-63-1
Package:500g/;1kg/;10kg/;25kg/;100kg/
Company Name: Henan Fengda Chemical Co., Ltd
Tel: +86-371-86557731 +86-13613820652
Email: info@fdachem.com
Products Intro: Product Name:4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
CAS:479633-63-1
Purity:99% Package:1KG;5USD|1000KG;0.1USD
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-（0）57185586718 +86-13336195806
Email: sales@capot.com
Products Intro: Product Name:4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine
CAS:479633-63-1
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Shanghai Daken Advanced Materials Co.,Ltd
Tel: +86-371-66670886
Email: info@dakenam.com
Products Intro: Product Name:4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE
CAS:479633-63-1
Purity:99% Package:100g ;1KG ;5KG 25KG

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine manufacturers
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Basic information
Product Name:4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
Synonyms:Tofacitinib Impurity R;4-Chloro-7-(p-tolylsulfonyl)pyrrolo[2,3-d]pyrimidine;4-CHLORO-7-[(4-METHYLPHENYL)SULFONYL]-7H-PYRROLO[2,3-D]PYRIMIDINE;4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE;4-Chloro-7-tosyl-7H-pyrro...;4-Chloro-7-[(4-methylbenzene)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine;4-Chloro-7-p-toluenesulphonyl-7H-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-D]pyriMidine,4-chloro-7-[(4-Methylphenyl)sulfonyl]-
CAS:479633-63-1
MF:C13H10ClN3O2S
MW:307.76
EINECS:811-000-2
Product Categories:Heterocycle-Pyrimidine series;ADVANCED INT.
Mol File:479633-63-1.mol
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Structure
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties
Melting point 145.0 to 149.0 °C
Boiling point 505.3±60.0 °C(Predicted)
density 1.49
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), DMSO (Slightly)
form powder to crystal
pka1.73±0.30(Predicted)
color White to Orange to Green
InChIInChI=1S/C13H10ClN3O2S/c1-9-2-4-10(5-3-9)20(18,19)17-7-6-11-12(14)15-8-16-13(11)17/h2-8H,1H3
InChIKeyBTOJSYRZQZOMOK-UHFFFAOYSA-N
SMILESC1=NC(Cl)=C2C=CN(S(C3=CC=C(C)C=C3)(=O)=O)C2=N1
Safety Information
Hazard Codes Xn
Risk Statements 22
HazardClass IRRITANT
HS Code 2933599590
MSDS Information
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Usage And Synthesis
Uses4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine is a reagent in the synthesis of (+)-tofacitinib, a selective Janus kinase 3 inhibitor (JAK3) and an immunosuppressant drug.
Synthesis 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine (2kg, 12.96mol) and dichloromethane (40L) were added to the reaction flask at room temperature, stirred and dissolved. Triethylamine (3.88 kg, 38.4 mol) and 4-dimethylamino pyridine (157.6 g, 1.28 mol) were added in that order, and after stirring and dissolved, p-toluenesulfonyl chloride (2.6 kg, 13.6 mol) was added dropwise at 0 °C. The chloromethane (30 L) solution was added dropwise, and the mixture was stirred at room temperature for 30 min. After the TLC was applied, the mixture was washed with water (16L×3). 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (3.9 kg, yield 97.7%) was obtained after drying under reduced pressure.
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials
Raw materialsTosyl chloride-->2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE-->4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
Preparation Products4-IODO-7-[(4-METHYLPHENYL)SULFONYL]-7H-PYRROLO[2,3-D]PYRIMIDINE
Tag:4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine(479633-63-1) Related Product Information
N-Methyl-N-((3S,4S)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]- (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride DEAZAPURINE 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Trifluorothymine 3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 4-Amino-7H-pyrrolo[2,3-d]pyrimidine 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 2-Thiouracil 2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE 4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine Pyrrolo[2,3-d]pyrimidin-4-ol N4-Benzoylcytosine 4-Aminopyrazolo[3,4-d]pyrimidine 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine Tofacitinib Impurity T