羟基伊曲康唑(伊曲康唑代谢物)
| 中文名称 | 羟基伊曲康唑(伊曲康唑代谢物) |
|---|---|
| 中文同义词 | 伊曲康唑代谢物;伊曲康唑2-羟基代谢物;羟基伊曲康唑;羟基伊曲康唑(伊曲康唑代谢物);伊曲康唑杂质1;依曲康唑杂质;伊曲康唑杂质8;2H6]-羟基曲康唑 |
| 英文名称 | HYDROXY ITRACONAZOLE |
| 英文同义词 | HYDROXY ITRACONAZOLE;3H-1,2,4-Triazol-3-one, 4-4-4-4-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenyl-1-piperazinylphenyl-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-;4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-3H-1,2,4-triazol-3-one;R 63373;4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-Methylpropyl)-;Itraconazole 2-Hydroxy Metabolite;Itraconazole metabolite Hydroxy Itraconazole;Itraconazole Impurity 8(Hydroxy Itraconazole) |
| CAS号 | 112559-91-8 |
| 分子式 | C35H38Cl2N8O5 |
| 分子量 | 721.63 |
| EINECS号 | |
| 相关类别 | 对照品-杂质对照品;临床检测标准物质;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Various Metabolites and Impurities;Isotooe labelled metabolites;metabolites;Isotopically Labeled Pharmaceutical Reference Standard |
| Mol文件 | 112559-91-8.mol |
| 结构式 |  |
羟基伊曲康唑(伊曲康唑代谢物) 性质
| 熔点 | 76-78°C |
|---|---|
| 沸点 | 884.7±75.0 °C(Predicted) |
| 密度 | 1.44±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C Freezer |
| 溶解度 | 可溶于氯仿（少许）、乙酸乙酯（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.72±0.20(Predicted) |
| 颜色 | 白色至浅棕色 |
Antifungal
Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ). Although Hydroxy Itraconazole is also reported to have antifungal activity in vitro, its pharmacokinetics in humans has been studied less than that of ITZ. ITZ and Hydroxy Itraconazole have a triazole ring and inhibit CYP3A. Their half-lives can be extended by 26-60% with repeated administration compared to single administration.
The plasma concentration of Hydroxy Itraconazole is weakly dependent on the dose of ITZ, most likely because the process that forms Hydroxy Itraconazole is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and Hydroxy Itraconazole. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of Hydroxy Itraconazole. However, the pharmacokinetics of Hydroxy Itraconazole is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and Hydroxy Itraconazole are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-12772 | 羟基伊曲康唑(伊曲康唑代谢物) Hydroxy Itraconazole | 112559-91-8 | 1mg | 1900元 |
| 2024/04/30 | HY-12772 | 羟基伊曲康唑(伊曲康唑代谢物) Hydroxy Itraconazole | 112559-91-8 | 5mg | 7500元 |