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4-fluoro-2-Methoxy-5-nitroaniline

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CAS:1075705-01-9
Purity:98% Package:100G, 5KG, 25KG or as request Remarks:Commercial stage
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CAS:1075705-01-9
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4-fluoro-2-Methoxy-5-nitroaniline Basic information
Product Name:4-fluoro-2-Methoxy-5-nitroaniline
Synonyms:4-fluoro-2-Methoxy-5-nitroaniline;2-Amino-5-fluoro-4-nitroanisole, 4-Fluoro-5-nitro-o-anisidine;4-Fluoro-2-Methoxy-5-nitrobenzenaMine;Benzenamine, 4-fluoro-2-methoxy-5-nitro-;4-fluoro-2-methoxy-5-nitrophenylamine;4-Fluoro-2-methoxy-5-nitroaniline 95+%;AZD9291 intermediates;uoro-2-methoxy-5-nitroaniL
CAS:1075705-01-9
MF:C7H7FN2O3
MW:186.14
EINECS:806-172-0
Product Categories:AZD9291;API;1075705-01-9
Mol File:1075705-01-9.mol
4-fluoro-2-Methoxy-5-nitroaniline Structure
4-fluoro-2-Methoxy-5-nitroaniline Chemical Properties
Melting point 130 °C
Boiling point 354.8±37.0 °C(Predicted)
density 1.412±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
form powder to crystal
pka2.31±0.10(Predicted)
color Light yellow to Brown
InChIInChI=1S/C7H7FN2O3/c1-13-7-2-4(8)6(10(11)12)3-5(7)9/h2-3H,9H2,1H3
InChIKeyFYSIGSQCZXQTIH-UHFFFAOYSA-N
SMILESC1(N)=CC([N+]([O-])=O)=C(F)C=C1OC
Safety Information
HS Code 2921420090
MSDS Information
4-fluoro-2-Methoxy-5-nitroaniline Usage And Synthesis
Uses4-Fluoro-2-methoxy-5-nitroaniline is used as a reagent for preparing the anticancer drug Mereletinib.
Synthesis4-FLUORO-2-METHOXYANILINE(551 mg, 3.90 mmol) is dissolved in dichloromethane (39.0 mL), concentrated sulfuric acid (1.85 mL) is added dropwise with stirring under ice-cooling, and then concentrated nitric acid (267 μL, 5.85 mmol) is added dropwise. After stirring for 3 hours under ice-cooling, saturated aqueous sodium bicarbonate was added until pH 8 was reached. After washing with saturated aqueous sodium bicarbonate solution, washing with saturated brine, the organic layer was dried over sodium sulfate and evaporated under reduced pressure to obtain 675 mg of the 4-fluoro-2-Methoxy-5-nitroaniline (yield 93%).
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4-fluoro-2-Methoxy-5-nitroaniline Preparation Products And Raw materials
Preparation ProductsN-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine-->AZ 7550
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