- Ethynyltrimethylsilane
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- $10.00 / 1kg
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2024-04-24
- CAS:1583-59-1
- Min. Order: 1kg
- Purity: 99.6%
- Supply Ability: 100000
- 2,2-Difluoro-1,3-benzodioxole
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- $80.00 / 1KG
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2023-12-27
- CAS:1583-59-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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Product Name: | 2,2-Difluoro-1,3-benzodioxole | Synonyms: | difluoromethylenedioxybenzene;2,2-DIFLUORO-1,3-BENZODIOXOLE;2,2-DIFLUOROBENZODIOXOLE;2,2-DIFLUORO-BENZO[1,3]DIOXOLE;LABOTEST-BB LT01148491;1,2-[(Difluoromethylene)dioxy]benzene;2,2-Difluoro-1,3-benzodioxole 98%;2,2-Difluoro-1,3-benzodioxole98% | CAS: | 1583-59-1 | MF: | C7H4F2O2 | MW: | 158.1 | EINECS: | 216-431-4 | Product Categories: | | Mol File: | 1583-59-1.mol | ![2,2-Difluoro-1,3-benzodioxole Structure](CAS/GIF/1583-59-1.gif) |
| 2,2-Difluoro-1,3-benzodioxole Chemical Properties |
Boiling point | 129-130°C | density | 1,308 g/cm3 | refractive index | 1.443 | Fp | 129-130°C | storage temp. | 2-8°C | solubility | Chloroform, Methanol | form | Oil | color | Clear Colourless | BRN | 1307648 | InChIKey | DGCOGZQDAXUUBY-UHFFFAOYSA-N | LogP | 2.96 | CAS DataBase Reference | 1583-59-1(CAS DataBase Reference) |
Hazard Codes | Xi | Risk Statements | 36/37/38-43 | Safety Statements | 26-36/37/39-36/37 | RIDADR | UN1993 | WGK Germany | 3 | Hazard Note | Irritant | HazardClass | 3 | PackingGroup | III | HS Code | 2932990090 |
Provider | Language |
ALFA
| English |
| 2,2-Difluoro-1,3-benzodioxole Usage And Synthesis |
Uses | 2,2-Difluoro-1,3-benzodioxole is an intermediate compound which is used especially for the preparation of products for agricultural chemistry and for the synthesis of pharmaceutical products.
2,2-difluoro-1,3-benzodioxole is a useful difluoromethylated building block for the synthesis of various benzodioxole-containing pharmaceutical active compounds.
2-,3-,and 4-(Trifluoromethoxy)phenyllithiums: Versatile intermediates offering access to a variety of new organofluorine compounds.
Selective aliphatic fluorination by halogen exchange in mild conditions.
| Preparation | 2,2-Difluoro-1,3-benzodioxole is prepared by reaction of 2,2-dichloro-1,3-benzodioxole with potassium fluoride in the presence of an effective quantity of a catalyst selected from potassium hydrogen fluoride, sodium hydrogen fluoride, cesium hydrogen fluoride, rubidium hydrogen fluoride, and quaternary ammonium hydrogen fluoride.
https://patents.google.com/patent/US5432290A/en
| References | [1] E.Castagnetti, et al, Eur. J. Org. Chem., 2001, 2001(4), pp 691-695.
[2] L.Saint-Jalmes, J. F. Chem., 2006, 127(1), pp 85-90.
| Chemical Properties | Colorless to pale yellow liquid | Uses | 2,2-Difluoro-1,3-benzodioxole is used in the synthesis of Kv3 inhibitors as well as in the preparation of renin inhibitors. |
| 2,2-Difluoro-1,3-benzodioxole Preparation Products And Raw materials |
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