二氢丹参酮
中文名称 | 二氢丹参酮 |
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中文同义词 | 4,8-二甲基-8,9-二氢菲并[3,2-b]呋喃-7,11-二酮;二氢丹参酮;二氢丹参酮(标准品);二氢异丹参酮I;2-B]呋喃-7;8-二甲基-8;9-二氢菲并[3;去氢异丹参酮 I |
英文名称 | Dihydrotanshinone |
英文同义词 | Dihydroisotanshinone I;4,8-Dimethyl-8,9-dihydrophenanthro[3,2-b]furan-7,11-dione;Dihydrotanshinone;8,9-Dihydro-4,8-dimethylphenanthro[3,2-b]furan-7,11-dione;Phenanthro(3,2-B)furan-7,11-dione, 8,9-dihydro-4,8-dimethyl-;Dihydrotanshinone 4,8-Dimethyl-8,9-dihydrophenanthro[3,2-b]furan-7,11-dione;DIHYDROTANSHINON;4,8-Dimethyl-8,9-Dihydronaphtho[2,1-F][1]BenzofuraN-7,11-Dione |
CAS号 | 20958-18-3 |
分子式 | C18H14O3 |
分子量 | 278.3 |
EINECS号 | |
植物来源 | 丹参 |
相关类别 | 医药原料;分析标准品;中药标准品;中药对照品;对照品-中药对照品;分析试剂-标准品;标准品 -中药标准品;其它天然产物;医药化工类;天然产物;Herb extract |
Mol文件 | 20958-18-3.mol |
结构式 |
二氢丹参酮 性质
沸点 | 470.4±45.0 °C(Predicted) |
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密度 | 1.32±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | DMSO:3.33 mg/mL(11.97 mM;超声加热并加热至 40°C)H2O:< 0.1 mg/mL(不溶) |
形态 | 粉末 |
颜色 | 红色 |
STAT3
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Dihydroisotanshinone I can inhibit the migration of both androgen-dependent and androgen-independent prostate cancer cells. Dihydroisotanshinone diminishes the ability of prostate cancer cells to recruit macrophages and reduces the secretion of chemokine (C-C motif) ligand 2 (CCL2) from both macrophages and prostate cancer cells in a dose-dependent manner. It inhibits the protein expression of p-STAT3 and decreases the translocation of STAT3 into nuclear chromatin. It also suppresses the expression of tumor epithelial-mesenchymal transition genes, including RhoA and SNAI1. Pretreating the cells with dihydroisotanshinone I at concentrations ranging from 2.5 μM to 20 μM for 24 hours cause dose-dependent protection against hepatotoxicity induced by menadione. Adding dihydroisotanshinone I to freshly isolated hepatocytes at concentrations between 50 nM to 200 nM inhibit NADH-induced superoxide production dose-dependently.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2022/07/01 | HY-B1919 | 二氢丹参酮 Dihydroisotanshinone I | 20958-18-3 | 5mg | 1800元 |
2022/07/01 | HY-B1919 | 二氢丹参酮 Dihydroisotanshinone I | 20958-18-3 | 10mM * 1mLin DMSO | 2380元 |