(+)-儿茶素,儿茶酚,儿茶酸,邻苯二酚
中文名称 | (+)-儿茶素,儿茶酚,儿茶酸,邻苯二酚 |
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中文同义词 | (+)-儿茶素(一水物);(2R,3S)-2-(3,4-二羟基苯基)-3,4-二氢-1(2H)-苯并吡喃-3,5,7-三醇一水物;(+)-儿茶素,儿茶酚,儿茶酸,邻苯二酚;D(+)-儿茶精;D(+)-儿茶素(四水);D(+)-儿茶酸;反式-3,3ˊ,4ˊ,4,7-五羟基黄烷;四水合-D(+)儿茶素 |
英文名称 | (+)-CATECHIN HYDRATE |
英文同义词 | (+)-Catechin hydrate,(+)-Cyanidol-3, (2R,3S)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol;FK-027-13C,15N2;FR- 17027-13C,15N2;(+)-Catechin hydrate >=96.0% (suM of enantioMers, HPLC);(2R,3S)-2-(3,4-Dihydroxyphenyl)-chroman-3,5,7-triol hydrate;2-keto-4-methyl-6-phenyl-3,6-dihydro-1H-pyrimidine-5-carboxylic acid methyl ester;4-methyl-2-oxo-6-phenyl-3,6-dihydro-1H-pyrimidine-5-carboxylic acid methyl ester;BAS 00381104 |
CAS号 | 225937-10-0 |
分子式 | C15H16O7 |
分子量 | 308.29 |
EINECS号 | 684-232-3 |
相关类别 | 植提;标准品;分析标准品;植物提取物;植物生化提取物;小分子抑制剂;小分子抑制剂,天然产物;细胞生物;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;诊断试剂;各种化学试剂;微生物;植物激素及核酸类;生化试剂-植物激素及核酸类;标准品-中药标准品;对照品 |
Mol文件 | 225937-10-0.mol |
结构式 | ![]() |
(+)-儿茶素,儿茶酚,儿茶酸,邻苯二酚 性质
熔点 | 175-177 °C (anhydrous)(lit.) |
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比旋光度 | 26 º (C=1 IN H2O) |
储存条件 | 2-8°C |
溶解度 | 乙醇:可溶50mg/mL |
形态 | 粉末 |
颜色 | 黄色至黄色带棕褐色 |
旋光性 (optical activity) | [α]/D +26±2°, c = 1 in H2O |
Merck | 13,1912 |
BRN | 3595244 |
CAS 数据库 | 225937-10-0(CAS DataBase Reference) |
COX-1 1.4 μM (IC 50 ) |
(+)-Catechin exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC 50 of 1.4 μM. A dose-dependent reduction in color is observed after 24 hours of treatment with (+)-Catechin, and 54.76% of the cells are dead at the highest concentration of (+)-Catechin tested (160 μg/mL) whereas the IC 50 of (+)-Catechin is achieved at 127.62 μg/mL (+)-Catechin. A dose- and time-dependent increase in the induction of apoptosis is observed when MCF-7 cells are treated with (+)-Catechin. When compare to the control cells at 24 hours, 40.7 and 41.16% of the cells treated with 150 μg/mL and 300 μg/mL (+)-Catechin, respectively, undergo apoptosis. The expression levels of Caspase-3 , -8 , and -9 and p53 in MCF-7 cells treated with 150 μg/mL (+)-Catechin for 24 h increase by 5.81, 1.42, 3.29, and 2.68 fold, respectively, as compare to the levels in untreated control cells.
Animals treated with (+)-Catechin at the lowest tested dose, i.e., 50 mg/kg, p.o. have spent comparatively more time in exploring the novel object in the choice trial, however, the difference is not statistically significant. (+)-Catechin prevents the time-induced episodic memory deficits in a dose-dependent manner, the most effective being 200 mg/kg, p.o.. Treatment with (+)-Catechin prevents the rise in MPO level compare to DOX alone treatment group (21.98±9.44 and 36.76±4.39% in the hippocampus and the frontal cortex respectively).
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | 46302 | (+)-儿茶素水合物 (+)-Catechin hydrate, Thermo Scientific Chemicals | 225937-10-0 | 1g | 876元 |
2024/08/19 | 46302 | (+)-儿茶素水合物 (+)-Catechin hydrate, Thermo Scientific Chemicals | 225937-10-0 | 5g | 3395元 |