乙丙昔罗
中文名称 | 乙丙昔罗 |
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中文同义词 | 2-[4-(3,5-二甲基苯基氨基甲酰甲基)苯氧基]-2-甲基丙酸;乙丙昔罗;2-(4-(((3,5-二甲基苯胺)羰基)甲基)苯氧基)-2-甲基丙酸;2-[4-(3,5-二甲基苯基氨基甲酰甲基)苯氧基]-2-甲基丙酸,乙丙昔罗自由酸;化合物 T21318;2-(4-(2-((3,5-二甲基苯基)氨基)-2-氧代乙基)苯氧基)-2-甲基丙酸 |
英文名称 | Efaproxiral |
英文同义词 | 2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid;Efaproxiral;Efaproxiral free acid;faproxiral;EFAPROXIRALUM;2-[4-(3,5-Dimethylphenylcarbamoylmethyl)phenoxy]-2-methylpropionic acid;EFAPROXIRAL;EFAPROXIRAL FREE ACID;FAPROXIRAL;Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl- |
CAS号 | 131179-95-8 |
分子式 | C20H22NO4.Na |
分子量 | 341.4 |
EINECS号 | 1806241-263-5 |
相关类别 | Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals |
Mol文件 | 131179-95-8.mol |
结构式 |
乙丙昔罗 性质
熔点 | 48-50°C |
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沸点 | 554.5±50.0 °C(Predicted) |
密度 | 1.202±0.06 g/cm3(Predicted) |
储存条件 | Refrigerator |
溶解度 | 可溶于DMSO(少许)、甲醇(少许) |
形态 | 固体 |
酸度系数(pKa) | 3.26±0.10(Predicted) |
颜色 | 灰白色到棕褐色 |
haemoglobin (Hb)
Efaproxiral binds to only one pair of symmetry-related sites in the Hb central water cavity.
Efaproxiral readily crosses the red cell membrane in the presence of serum albumin solutions.
Efaproxiral is not inhibited from entering erythrocytes in the presence of an anion-channel blocking agent (DIDS).
Efaproxiral (150 mg/kg, i.p.) increase tumor oxygenation,and increase the tumor growth inhibition of radiotherapy over 5 days of treatment.
Efaproxiral reduces hemoglobin-oxygen binding affinity, which facilitates oxygen release from hemoglobin into surrounding tissues and potentially increases the pO(2) of the tumors
Animal Model: | Female C3H/HEJ mice (18–20 g), with radiation-induced fibrosarcoma tumor (RIF-1) cells xenograft |
Dosage: | 150 mg/kg |
Administration: | Intraperitoneal injection; prior to X Irradiation (4 Gy/day), for 5 days |
Result: | Significantly increased tumor oxygenation by 8.4 to 43.4 mmHg within 5 days, with maximum increases at 22–31 minutes after treatment. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-13619 | 乙丙昔罗 Efaproxiral | 131179-95-8 | 50mg | 700元 |
2024/08/19 | HY-13619 | 乙丙昔罗 Efaproxiral | 131179-95-8 | 10mM * 1mLin DMSO | 770元 |