- Palovarotene
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- $1.00 / 1g
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2020-01-13
- CAS:410528-02-8
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 1ton
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| | palovarotene Basic information |
| Product Name: | palovarotene | | Synonyms: | palovarotene;4-[(1E)-2-[5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]benzoic acid;Unii-28K6I5m16g;R 667;Ro 3300074;(E)-4-(2-(3-((1H-pyrazol-1-yl)Methyl)-5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid;Palovarotene(R 667);R 667;RO 3300074 | | CAS: | 410528-02-8 | | MF: | C27H30N2O2 | | MW: | 414.54 | | EINECS: | 200-258-5 | | Product Categories: | | | Mol File: | 410528-02-8.mol |  |
| | palovarotene Chemical Properties |
| Melting point | 249-252°C | | Boiling point | 592.3±50.0 °C(Predicted) | | density | 1.11 | | storage temp. | Refrigerator | | solubility | DMSO (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly, Heated) | | pka | 4.26±0.10(Predicted) | | form | Solid | | color | White to Off-White |
| | palovarotene Usage And Synthesis |
| Description | Palovarotene an orally bioavailable retinoic acid receptor γ (RARγ) agonist. It increases retinoic acid response element (RARE) activity and decreases NF-κB activity induced by IL-1β in primary mouse stromal cells in reporter assays when used at a concentration of 60 nM. Palovarotene (10 nM) inhibits activin A-induced chondrogenic and osteogenic differentiation of mouse fibro/adipogenic progenitors (FAPs) expressing a mutated form of human activin A receptor type I (ACVR1R206H). It inhibits heterotopic ossification and preserves limb movement and growth in a ACVR1R206H fibrodysplasia ossificans progressiva (FOP) mouse model. Palovarotene (1 mg/kg per day for 14 days) decreases heterotopic ossification by 50 to 60% in a rat model of traumatic blast injury. | | Uses | Palovarotene, is a highly selective retinoic acid receptor gamma (RAR-γ) agonist that is under investigation as a potential treatment for emphysema. | | Definition | ChEBI: Palovarotene is a stilbenoid. |
| | palovarotene Preparation Products And Raw materials |
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