6-氨基烟酰胺
| 中文名称 | 6-氨基烟酰胺 |
|---|---|
| 中文同义词 | 6-氨基尼克酰胺;6-氨基维生素PP;6-氨基烟酰胺;2-氨基吡啶-5-甲酰胺;6-氨基-3-吡啶甲酰胺;6-氨基烟酸酰胺;氨基烟酰胺;烟酰胺,6-氨基- |
| 英文名称 | 6-Aminopyridine-3-carboxamide |
| 英文同义词 | 6-azanylpyridine-3-carboxamide;Nicotinamide, 6-amino-;Nicotinamide, 6-amino- (8CI);WLN: T6NJ BZ EVZ;6-Aminonikotinsaeureamid [German];6-Aminonitoinamide;2-Amino-5-carbamoylpyridine;3-Pyridinecarboxamide, 6-amino- |
| CAS号 | 329-89-5 |
| 分子式 | C6H7N3O |
| 分子量 | 137.14 |
| EINECS号 | 206-349-7 |
| 相关类别 | 杂环化合物;酰胺;酰胺化合物;有机砌块;化工中间体;Heterocyclic Compounds;Building Blocks;C6;Chemical Synthesis;Heterocyclic Building Blocks;AMIDE;Pyridine series;Amines;Pyridines |
| Mol文件 | 329-89-5.mol |
| 结构式 |  |
6-氨基烟酰胺 性质
| 熔点 | 245-248 °C (lit.) |
|---|---|
| 沸点 | 251.97°C (rough estimate) |
| 密度 | 1.2620 (rough estimate) |
| 折射率 | 1.6910 (estimate) |
| 储存条件 | Keep in dark place,Inert atmosphere,Room temperature |
| 溶解度 | 不溶于水；不溶于乙醇； DMSO 中≥13.7 mg/mL |
| 形态 | 粉末晶体 |
| 酸度系数(pKa) | 15.66±0.50(Predicted) |
| 颜色 | 白色至浅黄色至浅橙色 |
| 水溶解性 | Soluble in Dimethyl sulfoxide (DMSO). Insoluble in water. |
| BRN | 116042 |
| CAS 数据库 | 329-89-5(CAS DataBase Reference) |
| NIST化学物质信息 | Nicotinamide, 6-amino-(329-89-5) |
| EPA化学物质信息 | 6-Aminonicotinamide (329-89-5) |
| Target | Value |
|
G6PD
(Cell-free assay) | 0.46 μM(Ki) |
6-Aminonicotinamide (100 nM; 7 days) causes a significant decrease in the human AR+, hormone-sensitive prostate cancer cell lines LNCaP and LAPC4, as well as the CRPC-derivative C4-2 and 22Rv1 cell models. 6-Aminonicotinamide (100 nM ± 10 nM R1881 as indicated for 3 days) increases both basal- and R1881-mediated ROS levels, suggesting 6-Aminonicotinamide is blocking the cells' antioxidant defense. 6-Aminonicotinamide also increases ROS levels in C4-2 cells.
6-Aminonicotinamide (20 mg/kg; i.p.; thress times; days 1, 10 or 11, and 21) alone induces a small but significant tumor growth delay (4.3+/-0.8 days). Treatment with 6-Aminonicotinamide followed by radiation induces a tumor growth delay of 57.0+/-3.8 days in CD8F1 breast tumor model.
安全信息
| 提供商 | 语言 |
|---|---|
|
英文
|
|
|
中文
|
|
|
英文
|