FG-7142
| 中文名称 | FG-7142 |
|---|---|
| 中文同义词 | Β-CARBOLINE-3-CARBOXYLIC ACID N-METHYLAMIDE;化合物FG 7142;N-甲基-9H-吡啶[3,4-B]吲哚-3-甲酰胺;FG 7142,苯二氮卓类反向激动剂 |
| 英文名称 | N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE |
| 英文同义词 | 4-b)indole-3-carboxamide,n-methyl-9h-pyrido(;n-methyl-9h-pyrido(3,4-b)indole-3-carboxamide;FG 7142;N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE;B-carboline-3-carboxylic acid N-*methylamide;N-METHYL-B-CARBOLINE-3-CARBOXAMIDE (FG-7 142);beta-carboline-3-carboxylic acid N-methylamide;β-Carboline-3-carboxylic acid N-methylamide |
| CAS号 | 78538-74-6 |
| 分子式 | C13H11N3O |
| 分子量 | 225.25 |
| EINECS号 | |
| 相关类别 | GABA/Glycine receptor |
| Mol文件 | 78538-74-6.mol |
| 结构式 |  |
FG-7142 性质
| 沸点 | 576.3±30.0 °C(Predicted) |
|---|---|
| 密度 | 1.328±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 乙醇：1 mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 13.44±0.46(Predicted) |
| 颜色 | 驼色 |
Ki: 91 nM (GABAA receptor)
FG-7142 has affinity for those expressing the α subunit, the K i values are 91 nM; 330 nM; 492 nM and 2.150 μM for α1, α2,α3 and α5 subunits, respectively. FG-7142 has a high efficacy in modulating GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC 50 = 137 nM) as compared to the other α subunits (EC 50 : α2= 507 nM,α3=1.021μM , α5=1.439 μM).
FG-7142 (intraperitoneal injection; 15-30 mg/kg) activates mesolimbocortical dopaminergic projections, leading to increases in dopamine in the prefrontal cortex and the nucleus accumbens in rats. FG-7142 (intraperitoneal injection; 15 mg/kg) increases tyrosine hydroxylase activity and dopamine turnover in the medial prefrontal cortex and ventral tegmentum in vivo, but effects are not detected in mesolimbic or nigrostriatal areas.
安全信息
| WGK Germany | 3 |
|---|---|
| RTECS号 | UU9780100 |
| 提供商 | 语言 |
|---|---|
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-100991 | FG-7142 FG 7142 | 78538-74-6 | 2mg | 500元 |
| 2024/04/30 | HY-100991 | FG-7142 FG 7142 | 78538-74-6 | 5mg | 1000元 |