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Sb-742457

Sb-742457 Suppliers list
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Products Intro: Product Name:Sb-742457
CAS:607742-69-8
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CAS:607742-69-8
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Products Intro: Product Name:SB742457
CAS:607742-69-8
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CAS:607742-69-8
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Products Intro: Product Name:Intepirdine
CAS:607742-69-8
Purity:98.99% Package:5mg;34USD|10mg;53USD|25mg;107USD Remarks:REAGENT;FOR LABORATORY USE ONLY

Sb-742457 manufacturers

  • Intepirdine
  • Intepirdine pictures
  • $34.00 / 5mg
  • 2024-11-19
  • CAS:607742-69-8
  • Min. Order:
  • Purity: 98.99%
  • Supply Ability: 10g
  • Sb-742457
  • Sb-742457 pictures
  • $2.00 / 1kg
  • 2019-07-06
  • CAS:607742-69-8
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
Sb-742457 Basic information
Product Name:Sb-742457
Synonyms:Gsk 742457;Sb 742457;Sb-742457;3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline;SB 742457/GSK 742457;Quinoline, 3-(phenylsulfonyl)-8-(1-piperazinyl)-;SB742457:Intepirdine;Intepirdine(SB742457)
CAS:607742-69-8
MF:C19H19N3O2S
MW:353.44
EINECS:
Product Categories:Inhibitors;API
Mol File:607742-69-8.mol
Sb-742457 Structure
Sb-742457 Chemical Properties
Boiling point 608.3±45.0 °C(Predicted)
density 1.292
storage temp. Store at -20°C
solubility insoluble in H2O; ≥17.65 mg/mL in DMSO; ≥2.13 mg/mL in EtOH with gentle warming and ultrasonic
pka8?+-.0.10(Predicted)
form solid
color Light yellow to yellow
Safety Information
MSDS Information
Sb-742457 Usage And Synthesis
DescriptionSB-742457 is an orally bioavailable antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 1.4 nM). SB-742457 (1 μM) also binds to 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors with high affinity. SB-742457 reduces 5-HT6 activation of Gs-mediated cAMP production in a concentration-dependent manner with an EC50 value of 21 nM in NG108-15 neuroblastoma cells. In vivo, SB-742457 (1.5 mg/kg, p.o.) reverses deficits in novel object recognition induced by scopolamine in rats. It also reverses age-induced impairments in spatial memory acquisition and retention in rats in the Morris water maze. SB-742457 (3.0 mg/kg, i.p.) reduces the number of licking bouts by 24% compared with control in rats trained to lick a glucose solution, indicating a role in satiety and obesity management.
UsesSB 742457 is a selective 5-HT6 receptor antagonist which is known to be involved in improving cognitive function.
target5-HT6
references[1] aaron t. t. chuang, andrew foley, perdita l. pugh, david sunter, xin tong, ciaran regan, lee a. dawson, andrew d. medhurst, neil upton.5-ht6 receptor antagonist sb-742457 as a novel cognitive enhancing agent for alzheimer’s disease. alzheimer's & dementia: the journal of the alzheimer's association volume 2, issue 3, supplement, pages s631–s632, july 2006
Sb-742457 Preparation Products And Raw materials
Tag:Sb-742457(607742-69-8) Related Product Information
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