VU0357017
中文名称 | VU0357017 |
---|---|
中文同义词 | 盐酸 VU 0357017;VU 0357017盐酸盐;4-((2-(2-甲基苯甲酰氨基)乙基)氨基)哌啶-1-羧酸乙酯盐酸盐;优选]VU 0357017 HYDROCHLORIDE |
英文名称 | VU 0357017 hydrochloride |
英文同义词 | VU 0357017 hydrochloride;4-[[2-[(2-Methylbenzoyl)aMino]ethyl]aMino]-1-piperidinecarboxylic Acid Ethyl Ester Hydrochloride;4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride;CID 25010775;Ethyl 4-(2-(2-methylbenzamido)ethylamino)piperidine-1-carboxylate hydrochloride;ML071 hydrochloride;SID 56353039;VU0357017 monohydrochloride |
CAS号 | 1135242-13-5 |
分子式 | C18H28ClN3O3 |
分子量 | 369.9 |
EINECS号 | |
相关类别 | 抑制剂;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Positive allosteric modulator of muscarinic M1 receptors.;Amines |
Mol文件 | 1135242-13-5.mol |
结构式 |
VU0357017 性质
储存条件 | Inert atmosphere,2-8°C |
---|---|
溶解度 | 二甲基亚砜:≥10mg/mL |
形态 | 粉末 |
颜色 | 白色至类白色 |
Target | Value |
M1 mAChR
(Cell-free assay) | 477 nM(EC50) |
M1 mAChR
(Cell-free assay) | 9.91 μM(Ki) |
VU0357017 is selective for M
1
(K
i
=9.91 µM) over M
2
-M
5
mAChRs (K
i
=21.4, 55.3, 35.0, and 50.0 μM, respectively) in CHO cells.
VU0357017 (1 nM-100 μM) induces calcium release and ERK phosphorylation in a concentration-dependent manner in CHO cells.
VU0357017 (1-10 mg/kg, i.p.) reverses scopolamine-induced disruption of the contextual fear conditioning response.
Animal Model: | Male Sprague−Dawley rats (380-420 g) were pretreated with scopolamine |
Dosage: | 1, 3, 10 mg/kg |
Administration: | A single i.p. |
Result: | Produced a significant reversal of the scopolamine-induced deficits at a dose of 10 mg/kg. |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-19752A | VU0357017 VU0357017 hydrochloride | 1135242-13-5 | 5mg | 580元 |
2024/08/19 | HY-19752A | VU0357017 VU0357017 hydrochloride | 1135242-13-5 | 10mM * 1mLin DMSO | 638元 |