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| | CAY10415 Basic information |
| Product Name: | CAY10415 | | Synonyms: | CAY10415;MSDC-0160;2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-;CAY10415 (Mitoglitazone);Mitoglitazone;5-[[4-[2-(5-ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-Thiazolidinedione;5-(4-(2-(5-Ethylpyridin-2-yl)-2-oxoethoxy)-benzyl)thiazolidine-2,4-dione;CAY10415;CAY-10415;CAY 10415;MSDC 0160;MSDC0160 | | CAS: | 146062-49-9 | | MF: | C19H18N2O4S | | MW: | 370.42 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 146062-49-9.mol |  |
| | CAY10415 Chemical Properties |
| Boiling point | 623.8±55.0 °C(Predicted) | | density | 1.315±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | ≥37 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O | | form | A crystalline solid | | pka | 6.32±0.50(Predicted) |
| | CAY10415 Usage And Synthesis |
| Uses | CAY10415 is used to study blood glucose levels and rates of insulin-stimulated lipogenesis. | | Definition | ChEBI: 5-[[4-[2-(5-ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]thiazolidine-2,4-dione is an aromatic ether. | | Biological Activity | msdc-0160 is a prototype mtot-modulating insulin sensitizer [1].msdc-0160 is a thiazolidinedione insulin sensitizer without the peroxisome proliferator–activated receptor-γ (ppar-γ)-dependent side effects. co-incubation of islets with msdc-0160 and igf-1 reduces the resistance of insulin-signaling pathway and preserves insulin content. msdc-0160 at 50μm alone also prevents the loss of insulin content significantly. besides that, treatment of msdc-0160 increases the phosphorylation of ampk and reduces mtor phosphorylation. moreover, msdc-0160 is also found to display pro-survival effects in human islets via reducing the level of cleaved caspase-3 and increasing the expression of apoptosis-related genes such as bcl2. in addition, msdc-0160 exerts prevention of nuclear translocation with β-catenin localized on the cell membrane or cytoplasm in human β-cells [1]. | | references | [1] rohatgi n, aly h, marshall c a, et al. novel insulin sensitizer modulates nutrient sensing pathways and maintains β-cell phenotype in human islets. plos one, 2013, 8(5): e62012. |
| | CAY10415 Preparation Products And Raw materials |
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