- Aminooxy-PEG2-azide
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- $0.00 / 500mg
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2024-04-02
- CAS:1043426-13-6
- Min. Order: 500mg
- Purity: >98.00%
- Supply Ability: 500mg
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| Aminooxy-PEG2-azide Basic information |
| Aminooxy-PEG2-azide Chemical Properties |
solubility | Soluble in Water, DMSO, DMF, DCM | form | Liquid | color | Colorless to light yellow |
| Aminooxy-PEG2-azide Usage And Synthesis |
Description | Aminooxy-PEG2-azide contain an azide and an aminooxy group. The aminooxy group reacts with an aldehyde or ketone group to form a oxime linkage. The azide group enables Click Chemistry. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | Biological Activity | Aminooxy-PEG2-azide is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules.It is also a non-cleavable ADC linker containing 2-unit PEG, which can be used to synthesize antibody drug conjugates (ADCs). | in vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | target | |
| Aminooxy-PEG2-azide Preparation Products And Raw materials |
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