腺苷-5'-单磷酸一水合物
中文名称 | 腺苷-5'-单磷酸一水合物 |
---|---|
中文同义词 | 腺苷-5'-磷酸(一水);腺苷-5-磷酸;腺苷-5'-磷酸;腺苷-5'-单磷酸一水合物;5'-磷酸腺苷,AMP;腺苷-5`-单磷酸水合物;腺苷-5'-磷酸,一水(+4℃);5'-单磷酸腺苷(>95%,BR) |
英文名称 | Adenosine 5'-monophosphate monohydrate |
英文同义词 | ADENOSINE 5'-MONOPHOSPHATE FREE ACID97+% FROM YEAS;5'-AMP=Adenylicacid;ADENOSINE-5'-MONOPHOSPHATE 1-HYDRATE;5'-AMP H2O;5'-AMP MONOHYDRATE;ADENOSINE 5'-MONOPHOSPHATE MONOHYDRATE;ADENOSINE 5'-MONOPHOSPHORIC ACID MONOHYDRATE;ADENYLIC ACID MONOHYDRATE |
CAS号 | 18422-05-4 |
分子式 | C10H16N5O8P |
分子量 | 365.24 |
EINECS号 | 200-500-0 |
相关类别 | 小分子抑制剂;试剂;核苷酸类;核苷,核苷酸,寡核苷酸;生化试剂;Nucleotides and Nucleic Acids;核酸;nucleoside;生化试剂-植物激素及核酸类;有机化学;食品添加剂;通用生化试剂-核酸;标准品 |
Mol文件 | 18422-05-4.mol |
结构式 |
腺苷-5'-单磷酸一水合物 性质
熔点 | 183-188 °C (dec.)(lit.) |
---|---|
比旋光度 | -48 º (c=2% in 2% NaOH) |
FEMA | 4224 | ADENOSINE MONOPHOSPHATE; MONOSODIUM, OR DISODIUM ADENYLATE |
储存条件 | -20°C |
溶解度 | H2O:加入弱碱溶 |
形态 | 固体 |
颜色 | 白色至类白色 |
Merck | 14,158 |
BRN | 5205540 |
CAS 数据库 | 18422-05-4(CAS DataBase Reference) |
Adenosine A 1 receptor
Adenosine 5'-monophosphate monohydrate is an adenosine A1 receptor agonist. Adenosine 5'-monophosphate monohydrate (5′-AMP)-induced cell toxicity is negligible at concentrations of 25 to 400 μM in RAW264.7 cells. Adenosine 5'-monophosphate monohydrate significantly attenuates the mRNA expression of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 in RAW264.7 cells. The dose-dependence of TNF-α and IL-6 mRNA show that at concentration of 400 μM, Adenosine 5'-monophosphate monohydrate exhibits the maximum inhibition. Exposure of cells to Adenosine 5'-monophosphate monohydrate significantly reduces recruitment of NF-κB p65 to TNF-α, IL-6, and IL-1β gene promoters.
C57BL/6J mice treated with Adenosine 5'-monophosphate monohydrate (5′-AMP) markedly increases hepatic adenosine level. Survival rate in PBS-treated mice (n=15) is 60% (8 h) and 33.3% (24 h), whereas survival rate in Adenosine 5'-monophosphate monohydrate-treated mice (n=15) is 100% (8 h) and 93.3% (24 h). Serum aspartate transaminase (AST) and alanine transaminase (ALT) levels are significantly lowered in the Adenosine 5'-monophosphate monohydrate group than in the vehicle group. The area and extent of necrosis is attenuated and the infiltration of inflammatory cells is reduced in the Adenosine 5'-monophosphate monohydrate group.
提供商 | 语言 |
---|---|
英文
|
|
中文
|
|
英文
|
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-A0181A | 腺苷-5'-单磷酸一水合物 Adenosine 5'-monophosphate monohydrate | 18422-05-4 | 500mg | 400元 |
2024/08/19 | HY-A0181A | 腺苷-5'-单磷酸一水合物 Adenosine 5'-monophosphate monohydrate | 18422-05-4 | 10mM * 1mLin Water | 500元 |