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| | AC-YVAD-PNA Basic information |
| Product Name: | AC-YVAD-PNA | | Synonyms: | AC-TYR-VAL-ALA-ASP-PNA;N-ACETYL-TYR-VAL-ALA-ASP-P-NITROANILIDE PNA;N-acetyl-tyr-val-ala-asp P-nitroanilide;AC-TYR-VAL-ALA-ASP-PNA: AC-YVAD-PNA;REF DUPL: Ac-Tyr-Val-Ala-Asp-pNA;CASPASE-1 SUBSTRATE IV, COLORIMETRIC;CASPASE-1 SUBSTRATE (CHROMOGENIC);CASPASE 1 (ICE) SUBSTRATE 2, CHROMOGENIC | | CAS: | 149231-66-3 | | MF: | C29H36N6O10 | | MW: | 628.63 | | EINECS: | | | Product Categories: | Caspase/Related Products;Pepetides;Peptide | | Mol File: | 149231-66-3.mol |  |
| | AC-YVAD-PNA Chemical Properties |
| Boiling point | 1108.9±65.0 °C(Predicted) | | density | 1.362±0.06 g/cm3(Predicted) | | storage temp. | -15°C | | pka | 4.04±0.10(Predicted) | | form | powder | | color | white to beige |
| | AC-YVAD-PNA Usage And Synthesis |
| Uses | N-Acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-α-asparagine is a substrate whose amino acids YVAD have been shown to be a preferred cleavage site for caspase-1 and -4. | | Biological Activity | Ac-YVAD-pNA is a very selective chromogenic substrate for caspase-1, a key mediator of inflammatory processes formerly known as interleukin (IL)-1-converting enzyme. Ac-YVAD-pNA is used to determine caspase-1 activity. Cleavage of Ac-YVAD-pNA by caspase-1 releases pNA (p-nitroanilide), which can be quantified spectrophotometrically at 405 nm. |
| | AC-YVAD-PNA Preparation Products And Raw materials |
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