AICAR

Price	$1307
Package	100G

Product Details

Product Name: AICAR	CAS No.: 2627-69-2
EC-No.: 220-097-5	Min. Order: 1G
Purity: 99%	Supply Ability: customise
Release date: 2019/07/06

WM0050 Article illustration

AICAR Basic information

adenosine regulating agents

Product Name:	AICAR
Synonyms:	ACADESINE;AICAR;AICA-RIBOSIDE;AMPK;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-RIBOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-B-D-RIBOFURANOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE 1-BETA-D-RIBOFURANOSIDE;Z-RIBOSIDE
CAS:	2627-69-2
MF:	C9H14N4O5
MW:	258.23
EINECS:	220-097-5
Product Categories:	Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides;Protein Kinase;ARASINE;Cardiovascular APIs;PI3K/Akt/mTOR;Akt;mTOR;PI3K
Mol File:	2627-69-2.mol

AICAR Chemical Properties

Melting point	214-215 °C
storage temp.	−20°C
solubility	H₂O: >10 mg/mL
form	powder
color	tan
Water Solubility	Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml
λmax	265nm(NaOH)(lit.)
Merck	14,16
InChIKey	RTRQQBHATOEIAF-UUOKFMHZSA-N
CAS DataBase Reference	2627-69-2(CAS DataBase Reference)
EPA Substance Registry System	1H-Imidazole-4-carboxamide, 5-amino-1-.beta.-D-ribofuranosyl- (2627-69-2)

Safety Information

Hazard Codes	Xi,T
Risk Statements	36/37/38-61
Safety Statements	26-36-45-53
WGK Germany	3
TSCA	Yes

MSDS Information

Provider	Language
SigmaAldrich	English

AICAR Usage And Synthesis

adenosine regulating agents	Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. Acadesine is a purine nucleosid analogue that enters the myocyte and is immediately phosphorylated to ZMP (AICA ribotide), which is further metabolised to Inosine mono-phosphate (an intermediate in the synthesis ofadenosine triphosphate (ATP) and guanosine triphos-phate). Claims that acadesine may serve as a substrate for ATP synthesis and result in repletion of myocardial ATP were supported by some studies and refuted by others. Because acadesine may be a precursor in the synthesis of myocardial ATP it was proposed as a possible agent of myocardial protection during ischaemia, particularly because myocardial ATP depletion has been linked to cell death.
Chemical Properties	Solid
Uses	glucose uptake stimulant; AMPK activator
Uses	AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
Definition	ChEBI: A 1-ribosylimidazolecarboxamide in which the carboxamide group is situated at position 4 of the imidazole ring, which is further substituted at position 5 by an amino group. A purine nucleoside analogue and activator of AMP-activated protein kinase, it is is used for the treatment of acute lymphoblastic leukemia and is reported to have cardioprotective effects.
Biological Activity	Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;

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Product Details

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career henan chemical co