中文名称
(±)-Hexanoylcarnitine chloride
英文名称
(±)-Hexanoylcarnitine chloride
英文别名
DL-CAPROYLCARNITINE CHLORIDE;(±)-Hexanoylcarnitine chloride;(3-carboxy-2-hexanoyloxypropyl)-trimethylazanium,hydrochloride;DL-Hexanoylcarnitine chloride;Ruthenium Red
Cas No.
6920-35-0
分子式
C13H25NO4
分子量
259.34
包装储存
4°C干燥保存。溶液中： -80°C, 6 个月; -20°C, 1 个月。
生物活性
(±)-Hexanoylcarnitine chloride is a fatty acid metabolite that breaks down fatty acids into energy that can be used by the body. (±)-Hexanoylcarnitine chloride also serves as a specific and easily detectable biomarker for rat skeletal muscle toxicity. Cerivastatin (HY-129458) and TMPD (HY-W012145) induce an increase in Hexanoylcarnitine in rats in a metabolomic analysis of the rectus femoris muscle. In type 2 diabetes, Hexanoylcarnitine is also significantly associated with and improves prediction of all-cause mortality. Hexanoylcarnitine is a biomarker for the identification of novel pathogenic pathways[1][2].
性状
Solid
体外研究(In Vitro)
No data available.
体内研究(In Vivo)
No data available.
运输条件
常温或者冷藏运输。产品对运输温度不敏感。
储存方式
4°C干燥保存。溶液中： -80°C, 6 个月; -20°C, 1 个月。
描述&特点
(±)-Hexanoylcarnitine chloride 是一种脂肪酸代谢产物，能将脂肪酸分解成能够被身体利用的能量。(±)-Hexanoylcarnitine chloride 还可作为大鼠骨骼肌毒性特异性且易于检测的生物标志物。在股骨直肌代谢组学分析中，Cerivastatin (HY-129458) 和 TMPD (HY-W012145) 可引起大鼠体内 Hexanoylcarnitine 增加。在 2 型糖尿病中，Hexanoylcarnitine 还与全因死亡率显著相关并可改善全因死亡率的预测。Hexanoylcarnitine 是识别新型致病途径的生物标志物。
来源
No data available.
参考文献
[1]. Scarale MG, et al. Circulating Metabolites Associate With and Improve the Prediction of All-Cause Mortality in Type 2 Diabetes. Diabetes. 2022 Jun 1;71(6):1363-1370.
[2]. Obayashi H, et al. Plasma 2-hydroxyglutarate and hexanoylcarnitine levels are potential biomarkers for skeletal muscle toxicity in male Fischer 344 rats. J Toxicol Sci. 2017;42(4):385-396.
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